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Thyrotoxic periodic paralysis in a hispanic man.

K Saeian¹, P S Heckerling

¹Department of Medicine, University of Illinois, Chicago 60680.

Archives of Internal Medicine

|March 1, 1988

Summary

Thyrotoxic periodic paralysis, a rare condition, can affect Hispanic patients, presenting as sudden limb weakness. Prompt potassium replacement and thyroid treatment are key to recovery and prevention.

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Area of Science:

Endocrinology
Neurology
Genetics

Background:

Thyrotoxic periodic paralysis (TPP) is an endocrine-neuromuscular disorder characterized by episodic hypokalemic muscle paralysis.
TPP predominantly affects individuals of Asian descent, with rare reports in other ethnicities, including Hispanic populations.

Observation:

A 28-year-old Mexican male presented with acute bilateral lower extremity weakness following a high-carbohydrate meal.
Clinical presentation was associated with severe hypokalemia (serum potassium 2.1 mmol/L) and concurrent hyperthyroidism.

Findings:

Intravenous potassium chloride administration rapidly corrected hypokalemia and resolved the muscle weakness.
Propranolol treatment and subsequent radioiodine therapy (iodine 131) effectively prevented recurrent paralytic episodes.

Implications:

This case highlights that thyrotoxic periodic paralysis, though infrequent, should be considered in the differential diagnosis of acute weakness in Hispanic individuals.
Early recognition and management of TPP are crucial for preventing morbidity and improving patient outcomes.

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