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Multimodal Diagnostics of Microrheologic Alterations in Blood of Coronary Heart Disease and Diabetic Patients

Anastasia Maslianitsyna1, Petr Ermolinskiy1, Andrei Lugovtsov1,2

  • 1Physics Department, Lomonosov Moscow State University, 119991 Moscow, Russia.

Diagnostics (Basel, Switzerland)
|January 9, 2021
PubMed

Insights

Red blood cells aggregate more in patients with coronary heart disease (CHD) and type 2 diabetes mellitus (T2DM). Optical methods confirm these findings, aiding in early diagnosis and monitoring of these common conditions.

Area of Science:

  • Biomedical optics
  • Cardiovascular research
  • Hematology

Background:

  • Coronary heart disease (CHD) poses significant health risks, necessitating early diagnosis.
  • Red blood cell aggregation is a key blood property influencing cardiovascular health.
  • Comorbidities like type 2 diabetes mellitus (T2DM) can exacerbate CHD complications.

Purpose of the Study:

  • To investigate red blood cell aggregation in patients with CHD using in vivo and in vitro optical methods.
  • To compare aggregation parameters between CHD patients and healthy individuals.
  • To assess the impact of T2DM comorbidity on red blood cell aggregation in CHD patients.

Main Methods:

  • Utilized in vivo and in vitro optical techniques to analyze blood properties.
  • Measured and compared red blood cell aggregation indices in patient cohorts.
  • Correlated in vivo and in vitro findings to validate diagnostic approaches.

Main Results:

  • Significantly increased red blood cell aggregation observed in CHD patients compared to healthy controls.
  • Aggregation index elevated by 20 ± 7% in CHD patients.
  • T2DM presence further amplified red blood cell aggregation in CHD patients, showing a strong correlation.

Conclusions:

  • Multimodal optical methods effectively diagnose and monitor red blood cell aggregation in CHD.
  • Elevated aggregation is a distinct biomarker for CHD, further influenced by T2DM.
  • This approach offers potential for early detection and management of socially significant cardiovascular and metabolic diseases.

Keywords:
blood rheologycoronary heart diseasediabetes mellitusdigital capillaroscopylaser aggregometrylaser tweezersred blood cell aggregation

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