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Updated: Nov 22, 2025

Real Time Detection of In Vitro Tumor Cell Apoptosis Induced by CD8+ T Cells to Study Immune Suppressive Functions of Tumor-infiltrating Myeloid Cells
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Real Time Detection of In Vitro Tumor Cell Apoptosis Induced by CD8+ T Cells to Study Immune Suppressive Functions of Tumor-infiltrating Myeloid Cells

Published on: January 29, 2019

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Cancer Cells Resistance Shaping by Tumor Infiltrating Myeloid Cells

Marcin Domagala1,2,3, Chloé Laplagne1,2,3, Edouard Leveque1,2,3

  • 1Centre de Recherches en Cancérologie de Toulouse, Inserm UMR1037, 31037 Toulouse, France.

Cancers
|January 9, 2021
PubMed

Insights

Myeloid cells in the tumor microenvironment (TME) initially fight cancer but later promote tumor growth and resistance. Understanding these myeloid cells is key for developing new cancer therapies.

Area of Science:

  • Oncology
  • Immunology
  • Cell Biology

Background:

  • Malignant cell interactions with stromal and immune cells are crucial for cancer progression.
  • Novel therapies targeting these cells have transformed cancer treatment.
  • Understanding individual cell roles within the tumor microenvironment (TME) is essential.

Purpose of the Study:

  • To review the role of the myeloid cell compartment within the TME.
  • To elucidate how myeloid cells influence cancer progression and therapy resistance.

Main Methods:

  • Literature review focusing on myeloid cell populations in the TME.
  • Analysis of cellular interactions and soluble factors mediating myeloid cell functions.

Main Results:

  • Myeloid cells, initially anti-tumoral, become pro-tumoral during cancer progression.
  • Specific myeloid populations (macrophages, dendritic cells, neutrophils, MDSCs, mast cells, eosinophils, basophils) contribute to tumor growth and immune evasion.
  • These cells promote tumor cell survival, proliferation, migration, and therapy resistance.

Conclusions:

  • Myeloid cells are key players in shaping the TME and influencing cancer outcomes.
  • Targeting specific myeloid cell functions presents a promising strategy for overcoming treatment resistance.
Keywords:
cancer developmentmicroenvironmentmyeloid cellsresistance

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