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New Cyclic Diarylheptanoids from Platycarya strobilacea
Wen-Bing Ding1,2, Rui-Yuan Zhao3, Guan-Hua Li2
1Hunan Provincial Engineering and Technology Research Center for Biopesticide and Formulation Processing, Hunan Agricultural University, Changsha 410128, China.
Five new cyclic diarylheptanoids from Platycarya strobilacea stem bark were identified. Compounds 1 and 2 showed significant protection against corticosterone-induced apoptosis in PC12 cells.
Area of Science:
- Natural Product Chemistry
- Pharmacology
Background:
- Platycarya strobilacea stem bark is a source of bioactive compounds.
- Cyclic diarylheptanoids represent a class of natural products with potential therapeutic applications.
Purpose of the Study:
- To isolate and characterize new cyclic diarylheptanoids from Platycarya strobilacea.
- To evaluate the biological activities of isolated compounds, including cytotoxicity, nitric oxide inhibition, and neuroprotection.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation using Nuclear Magnetic Resonance (NMR), High-Resolution Electrospray Ionization Mass Spectrometry (HRESIMS), and Electronic Circular Dichroism (ECD) data.
- In vitro bioassays to assess cytotoxicity, nitric oxide inhibition, and apoptosis protection.
Main Results:
- Five new cyclic diarylheptanoids (platycary A-E) and three known analogues were isolated.
- Compounds 1-5 were evaluated for their biological activities.
- Compounds 1 and 2 demonstrated significant inhibition of corticosterone-induced apoptosis in Pheochromocytoma (PC12) cells at 20 μM.
Conclusions:
- Platycarya strobilacea stem bark yielded novel cyclic diarylheptanoids.
- Compounds 1 and 2 possess neuroprotective properties, offering potential for treating conditions involving apoptosis.
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