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New Cyclic Diarylheptanoids from Platycarya strobilacea
Wen-Bing Ding1,2, Rui-Yuan Zhao3, Guan-Hua Li2
1Hunan Provincial Engineering and Technology Research Center for Biopesticide and Formulation Processing, Hunan Agricultural University, Changsha 410128, China.
Abstract:
Five new cyclic diarylheptanoids (platycary A-E, compounds 1-5) and three previously identified analogues (i.e., phttyearynol (compound 6), myricatomentogenin (compound 7), and juglanin D (compound 8)) were isolated from the stem bark of Platycarya strobilacea. The structures of these compounds were determined using NMR, HRESIMS, and electronic circular dichroism (ECD) data. The cytotoxicity of compounds 1-5 and their ability to inhibit nitric oxide (NO) production, as well as protect against the corticosterone-induced apoptosis of Pheochromocytoma (PC12) cells, were evaluated in vitro using the appropriate bioassays. Compounds 1 and 2 significantly inhibited the corticosterone-induced apoptosis of PC12 cells at a concentration of 20 μΜ.
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