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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Updated: Nov 22, 2025

Biofunctionalization of Magnetic Nanomaterials
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Tumor Microenvironment-Specific Functional Nanomaterials for Biomedical Applications.

Linlu Zhao, Heng Liu, Yanlong Xing

    Journal of Biomedical Nanotechnology
    |January 9, 2021
    PubMed
    Summary
    This summary is machine-generated.

    Functional nanomaterials targeting the tumor microenvironment (TME) offer improved cancer imaging and drug delivery. This review highlights recent advances in TME-specific nanoplatforms for enhanced cancer theranostics.

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    Area of Science:

    • Biomedical Engineering
    • Nanoscience
    • Oncology

    Background:

    • The tumor microenvironment (TME) presents unique pathological and physicochemical conditions.
    • Developing targeted cancer therapies requires overcoming challenges associated with specificity and efficacy.
    • Functional nanomaterials offer a promising approach to address these challenges.

    Purpose of the Study:

    • To review the latest advancements in TME-specific functional nanomaterials for cancer theranostics.
    • To summarize stimulus-responsive nanosystems for targeted cancer drug delivery and diagnosis.
    • To highlight the potential of these nanomaterials in enhancing anticancer treatment efficiency.

    Main Methods:

    • Literature review of recent developments in TME-specific nanomaterials.
    • Analysis of various stimulus-responsive strategies employed by nanosystems.
    • Summary of applications in cancer drug delivery, diagnosis, and treatment.

    Main Results:

    • Significant progress has been made in designing nanoarchitectures for targeted cancer therapy.
    • Various nanosystems demonstrate specific responses to TME stimuli for enhanced therapeutic outcomes.
    • Multifunctional nanomaterials show potential for synergistic theranostics.

    Conclusions:

    • TME-specific functional nanomaterials are crucial for improving the specificity and efficacy of cancer imaging and drug delivery.
    • Stimulus-responsive strategies enhance the performance of nanosystems in targeting tumors.
    • Continued research in this area holds significant promise for nanoscience, biomedicine, and clinical applications.