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Updated: Nov 22, 2025

Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice
Published on: June 27, 2020
TRH cells, helpers making an impact in their local community
Stefan A Schattgen1, Paul G Thomas2
1Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Resident helper T cells (TRH) are a specialized immune cell type that helps regulate B cell immune responses within organs outside of lymph nodes. These cells combine properties of follicular helper T cells and resident memory T cells.
Area of Science:
- Immunology
- Cell Biology
Background:
- T resident helper cells (TRH) are a recently identified subset of T cells.
- These cells possess characteristics of both follicular helper T cells and resident memory T cells.
Purpose of the Study:
- To elucidate the role of TRH cells in immune regulation within nonlymphoid organs.
Main Methods:
- Investigated the properties and functions of TRH cells.
- Examined their interactions with B cells in specific tissue microenvironments.
Main Results:
- TRH cells were found to significantly influence B cell responses.
- These cells reside in and patrol nonlymphoid tissues, contributing to local immunity.
Conclusions:
- TRH cells are critical regulators of B cell activity in peripheral tissues.
- Understanding TRH cell function is key to developing strategies for organ-specific immunity and disease.
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