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Over-expression of CEP55 Predicts Favorable Prognosis in Colorectal Cancer Patients With Lymph Node Involvement
Ren-Hung Huang1, Wen-Kang Yang2, Cheuk Man Wu2
1Department of Pathology, Changhua Christian Hospital, Changhua, Taiwan, R.O.C.
Background/Aim:
To characterize the potential roles of CEP55 in colorectal cancer development and assess its eligibility as a prognostic diagnosis tool for colorectal cancer.
Patients And Methods:
Immunohistochemical (IHC) analysis of CEP55 immunoreactivity in 166 cancer specimens from colorectal cancer patients.
Results:
CEP55 was not found to statistically significantly affect different patient clinical parameters. Multivariate analysis illustrated that patients with N stage (1+2) colorectal cancer and high CEP55 expression had a significantly lower five-year survival rate than patients with N stage (1+2) colorectal cancer and low CEP55 expression.
Conclusion:
There is a correlation between CEP55 and advanced N-stage colorectal cancer. Thus, CEP55 may be a potential diagnostic biomarker for colorectal cancer patients.
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