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Amino acid metabolism in tumour-bearing mice
S Rivera1, J Azcón-Bieto, F J López-Soriano
1Department de Bioquímica i Fisiologia, Facultat de Biologia, Universitat de Barcelona, Spain.
The Biochemical Journal
|January 15, 1988
Abstract:
Mice bearing the Lewis lung carcinoma showed a high tumour glutaminase activity and significantly higher concentrations of most amino acids than in both the liver and the skeletal muscle of the host. Tumour tissue slices showed a marked preference for glutamine, especially for oxidation of its skeleton to CO2. It is proposed that the metabolism of this particular carcinoma is focused on amino acid degradation, glutamine being its preferred substrate.