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Effect of positive and negative expiratory pressure on renal function
British Journal of Anaesthesia
|March 1, 1977
Summary
Positive and negative end-expiratory pressure significantly impact kidney function. Positive pressure decreased urine output and filtration, while negative pressure had opposite effects in healthy greyhounds.
Area of Science:
- Physiology
- Nephrology
- Respiratory Medicine
Background:
- End-expiratory pressure (EEP) is used in mechanical ventilation.
- Its effects on renal function, particularly with both positive and negative pressures, require further elucidation.
Purpose of the Study:
- To investigate the impact of positive end-expiratory pressure (PEEP) and negative end-expiratory pressure (NEEP) on renal function in healthy adult greyhounds.
Main Methods:
- Adult greyhounds with normal blood volume and no cardiorespiratory disease were used.
- Measurements included urine volume, glomerular filtration rate (GFR), and renal blood flow (RBF).
- Effects of sustained positive ( + 10 cm H2O) and negative (-6 cm H2O) EEP were assessed.
Main Results:
- Positive end-expiratory pressure led to significant decreases in urine volume, GFR, and RBF.
- These renal function parameters returned towards baseline after cessation of positive pressure.
- Negative end-expiratory pressure induced opposing changes in renal function compared to positive pressure.
Conclusions:
- Both positive and negative end-expiratory pressure markedly alter renal hemodynamics and function.
- Understanding these effects is crucial for managing patients undergoing mechanical ventilation.
- Further research may explore clinical implications in various patient populations.