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Updated: Nov 22, 2025

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Published on: May 27, 2022
Thermal stability of cannabinoids in dried cannabis: a kinetic study
Juris Meija1, Garnet McRae2, Christopher O Miles3
1Metrology, National Research Council Canada, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada. juris.meija@nrc-cnrc.gc.ca.
Abstract:
This study was undertaken to quantitatively explore the effect of temperature on the degradation of cannabinoids in dried cannabis flower. A total of 14 cannabinoids were monitored using liquid chromatography and tandem mass spectrometry in temperature environments from - 20 to + 40 ∘C lasting up to 1 year. We find that a network of first-order degradation reactions is well-suited to model the observed changes for all cannabinoids. While most studies focus on high-temperature effects on the cannabinoids, this study provides high-precision quantitative assessment of room temperature kinetics with applications to shelf-life predictions and age estimates of cannabis products.
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