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Updated: Nov 22, 2025

Mouse In Vivo Placental Targeted CRISPR Manipulation

Mouse In Vivo Placental Targeted CRISPR Manipulation

Published on: April 14, 2023

Bioengineering Approaches for Placental Research.

Mackenzie L Wheeler¹, Michelle L Oyen²

¹Department of Engineering, East Carolina University, Greenville, NC, 27834, USA.

Annals of Biomedical Engineering

|January 9, 2021

Summary

This summary is machine-generated.

New bioengineering models, including computational simulations and cellular organoids, are advancing human placenta research. These tools help study placental development and function, crucial for understanding conditions like preterm birth.

Keywords:

Biomimetic Computational models Finite elements Hydrogels Microfluidics Organoids Tissue engineering Trophoblast

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Area of Science:

Bioengineering
Reproductive Biology
Computational Biology

Background:

The human placenta's complex function is difficult to study due to a lack of adequate in vivo models.
Understanding placental function is critical for addressing clinical issues such as preterm birth.

Purpose of the Study:

To review emerging computational (in silico) and cellular (in vitro) bioengineering approaches for studying the human placenta.
To highlight how these models can investigate placental development and function across gestation.

Main Methods:

Review of computational in silico techniques, including multi-scale modeling of placental blood flow and oxygen transport.
Review of cellular in vitro approaches, including organoids, tissue engineering, and organ-on-a-chip models.

Main Results:

Cellular techniques enable the study of early placental development, including trophoblast invasion and fusion.
Computational models facilitate investigation of later-term placental function and related complications.
Both approaches offer complementary insights into placental structure and function.

Conclusions:

A holistic approach combining in silico and in vitro methods is necessary for a comprehensive understanding of placental function.
These advanced models are vital for investigating placental development and its impact on pregnancy outcomes, including preterm birth.