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Swept-source optical coherence tomography objective composite activity score for uveitis.

Victor Llorenç1,2, Alba R Serrano1, Marina Mesquida2

  • 1Clínic Institute of Ophthalmology (ICOF), Clínic Hospital of Barcelona, Barcelona, Spain.

Acta Ophthalmologica
|January 9, 2021
PubMed
Summary
This summary is machine-generated.

A new swept-source optical coherence tomography (SS-OCT) score objectively measures intraocular inflammation. This SS-OCT-derived uveitis activity score (SS-UAS) reliably differentiates active from inactive uveitis and healthy eyes.

Keywords:
gradingimagingintraocular inflammationoptical coherence tomographyscorestagingswept-sourcethickness mapuveitis

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Biomarkers

Background:

  • Intraocular inflammation, such as uveitis, requires objective assessment for effective management.
  • Current methods for grading inflammation can be subjective and lack consistency.
  • Developing a quantitative, objective score is crucial for clinical trials and patient care.

Purpose of the Study:

  • To develop an objective composite score for intraocular inflammation using swept-source optical coherence tomography (SS-OCT).
  • To validate the SS-OCT-derived uveitis activity score (SS-UAS) for its ability to differentiate various inflammation states.

Main Methods:

  • A cross-sectional study involving patients with active uveitis, inactive uveitis, and healthy controls.
  • Acquisition of anterior and posterior segment images using SS-OCT.
  • Identification and selection of eight imaging biomarkers across anterior, intermediate, and posterior segments based on discriminatory power.
  • Development of the SS-UAS using multiple linear regression.

Main Results:

  • The study included 224 eyes with uveitis and 38 healthy eyes.
  • Key biomarkers for the SS-UAS included anterior chamber hyper-reflective dots, vitreous intensity, and retinal thickness index.
  • The SS-UAS demonstrated high discrimination between active uveitis, inactive uveitis, and healthy eyes (p < 0.001).
  • Favorable construct validity, internal consistency, criterion validity, and reliability (intra-rater CCC=0.99, inter-rater CCC=0.98) were observed.

Conclusions:

  • Objective staging and scoring of global intraocular inflammation are achievable using SS-OCT.
  • The developed SS-UAS offers a continuous, consistent, and valid method for assessing uveitis activity.
  • This objective scoring system has the potential to improve uveitis diagnosis and treatment monitoring.