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A Multiple Integrated Social Stress Model for Psychiatric Disorders in Female C57BL/6J Mice

A Multiple Integrated Social Stress Model for Psychiatric Disorders in Female C57BL/6J Mice

Published on: July 15, 2025

Modeling endophenotypes of suicidal behavior in animals.

Bhaskar Roy¹, Yogesh Dwivedi¹

¹Department of Psychiatry and Behavioral Neurobiology, 1720 7(th) Avenue South, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.

Neuroscience and Biobehavioral Reviews

|January 9, 2021

Summary

Genetic factors influence suicide risk through endophenotypic traits. Animal models help study these neurobiological abnormalities, advancing understanding and treatment for suicidal behavior.

Keywords:

Animal model Endophenotype Neurobiology Suicidal behavior

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Area of Science:

Neuroscience
Genetics
Psychiatry

Background:

Suicide is a significant public health issue.
Genetic factors contribute to suicide risk via endophenotypic traits.
Understanding these endophenotypes is crucial for suicide prevention.

Purpose of the Study:

To review neurobiological abnormalities linked to suicidal behavior.
To explore the potential of animal models in studying suicide endophenotypes.
To advance the understanding of genetic and epigenetic factors in suicidal behavior.

Main Methods:

Literature review focusing on genetic and epigenetic abnormalities.
Analysis of endophenotypic traits associated with suicidal behavior.
Discussion of animal modeling approaches for suicide research.

Main Results:

Genetic and epigenetic abnormalities are implicated in suicidal behavior.
Endophenotypic traits serve as quantifiable measures of neurobiological function.
Animal models offer a viable platform for investigating the neurobiology of suicide.

Conclusions:

Studying endophenotypes in animal models can enhance comprehension of suicidal behavior.
This approach may facilitate the development of novel treatments and risk assessment strategies.
Investigating genetic and epigenetic underpinnings is key to addressing suicide risk.