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Oestrogen and progesterone receptors in lentigo maligna
M E Sawaya1, L D Garland, M J Rothe
1Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Florida 33101.
The British Journal of Dermatology
|January 1, 1988
Abstract:
We have measured oestrogen and progesterone binding in specimens of histopathologically confirmed lentigo maligna (LM) lesions excised from five elderly white men, using a dextran-coated charcoal method. Oestrogen binding was observed in four of the five specimens, and progesterone binding in all five. Marginal normal skin showed only non-specific binding for oestrogen and progesterone. The presence of steroid hormone receptors in LM suggests the possibility that hormone responsiveness may be relevant in the transformation of a lentigo maligna into malignant melanoma.