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Oxycodone versus other opioid analgesics after laparoscopic surgery: a meta-analysis
Yan Li1,2,3, Zhi Dou3, Liqiang Yang3
1Department of Anesthesiology, The People's Hospital of Jizhou District, Tianjin, 301900, Tianjin, China.
European Journal of Medical Research
|January 10, 2021
Summary
Oxycodone offers superior pain relief within 24 hours after laparoscopic surgery compared to other opioids like morphine and fentanyl. However, its use is associated with increased dizziness and drowsiness, requiring careful consideration of adverse effects.
Area of Science:
- Anesthesiology
- Pharmacology
- Surgical Pain Management
Background:
- Intravenous opioids are standard for visceral pain post-laparoscopic surgery.
- The comparative efficacy of oxycodone versus other opioids for this pain is not well-established.
Purpose of the Study:
- To evaluate the analgesic efficacy and adverse events of oxycodone compared to other opioids for visceral pain after laparoscopic surgery.
Main Methods:
- Systematic review and meta-analysis adhering to Cochrane and PRISMA guidelines.
- Searched PubMed, Embase, and Cochrane databases in December 2019.
- Included 10 studies with 695 participants.
Main Results:
- Oxycodone demonstrated superior analgesic efficacy compared to morphine and fentanyl within the first 24 hours post-surgery, particularly in the initial 0.5 hours.
- No significant differences in sedation levels were observed.
- Oxycodone use was associated with a higher incidence of dizziness and drowsiness compared to morphine and fentanyl.
- Patient satisfaction levels were comparable across oxycodone and other opioid groups.
Conclusions:
- Oxycodone is more effective than other analgesics for managing visceral pain within 24 hours after laparoscopic procedures.
- The increased risk of adverse effects such as dizziness and drowsiness necessitates careful clinical consideration.
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