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Updated: Nov 22, 2025

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Rapid and severe neurologic deterioration due to influenza associated encephalopathy in a healthy child
Taylor Roth1, Dominic DiPrinzio1, Jay D Fisher1
1Children's Hospital of Nevada at UMC, 800 Hope Pl, Las Vegas, NV 89106, USA; University of Nevada, Las Vegas Emergency Medicine Residency, 901 Rancho Lane, Ste 135, Las Vegas, NV 89106, United States of America.
Insights
Rapid neurologic deterioration in children is rare. This case highlights a previously healthy child who experienced severe neurological injury within eight hours after mild viral symptoms, emphasizing the need for urgent evaluation.
Area of Science:
- Pediatric Neurology
- Neurological Emergencies
- Childhood Illness
Background:
- Rapid neurologic deterioration is uncommon in healthy school-aged children.
- Exclusion of trauma and toxic exposure is critical in initial assessments.
- Differential diagnoses include stroke, infections, and metabolic disorders.
Observation:
- A previously healthy child presented with two days of mild viral symptoms.
- The child experienced a rapid decline in neurological status over eight hours.
- Progression from playful to severe neurological injury was observed.
Findings:
- The case illustrates a rare instance of acute neurological decline in a pediatric patient.
- The rapid progression underscores the potential for severe neurological injury.
- The etiology remained to be determined but occurred post-viral symptoms.
Implications:
- Highlights the importance of prompt recognition and management of neurological emergencies in children.
- Suggests that even mild viral illnesses can precede severe neurological events.
- Emphasizes the need for a broad differential diagnosis in pediatric neurology.
Abstract:
Rapid neurologic deterioration is rare in healthy school age children, particularly in the absence of trauma or toxic exposure. Hemorrhagic or ischemic stroke, infectious etiologies and metabolic causes must be emergently considered. We present the clinical details of a previously well child with two days of mild viral symptoms who progressed from playful and active to severe neurologic injury over the course of eight hours.
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