Related Experiment Video
Updated: Nov 22, 2025
Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy
Published on: November 1, 2011
Pathogenicity comparison of the SMPV-11 and attenuated mink enteritis virus F61 in mink
Yang Wang1, Bo Hu2, Rongguang Lu2
1Key Laboratory of Special Animal Epidemic Disease, Ministry of Agriculture, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China; Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Abstract:
Mink enteritis virus (MEV) is a major pathogen inducing acute hemorrhagic enteritis in mink. This study aims to determine the pathogenicity of the isolated MEV strain (SMPV-11) compared with the attenuated MEV strain (MEV-F61) in the mink. The two MEV strains were inoculated in the two mink groups, respectively. Then the clinical symptom, hematological, serological, and histopathological change were evaluated. Our findings showed that there were differences in the clinical features and pathological changes of the SMPV-11 and MEV-F61 in the mink. It indicates that SMPV-11 is a virulent strain, and it can be the potential MEV vaccine strain in the mink.
Insights
Mink enteritis virus (MEV) causes severe enteritis. This study found the isolated SMPV-11 strain is virulent, unlike the attenuated MEV-F61 strain, suggesting SMPV-11
Area of Science:
- Veterinary Virology
- Pathogen Research
- Animal Health
Background:
- Mink enteritis virus (MEV) is a significant pathogen causing acute hemorrhagic enteritis in mink.
- Understanding the pathogenicity of different MEV strains is crucial for disease control and vaccine development.
Purpose of the Study:
- To compare the pathogenicity of an isolated MEV strain (SMPV-11) with an attenuated MEV strain (MEV-F61) in mink.
- To evaluate the clinical, hematological, serological, and histopathological changes induced by each strain.
Main Methods:
- Two groups of mink were inoculated with either the SMPV-11 or MEV-F61 strain.
- Clinical signs, blood parameters, antibody responses, and tissue damage were assessed post-inoculation.
Main Results:
- Distinct differences in clinical manifestations and pathological alterations were observed between the two groups.
- The SMPV-11 strain exhibited higher virulence compared to the attenuated MEV-F61 strain.
Conclusions:
- The isolated SMPV-11 strain is a virulent MEV strain.
- SMPV-11 shows potential as a candidate vaccine strain for MEV in mink.
