Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

pH Regulation in Cells01:28

pH Regulation in Cells

7.2K
pH plays a critical role in maintaining normal cellular activities. It helps maintain the structure and function of various proteins, dictates the charge on cellular membranes, and is crucial for metabolic reactions inside the cell. Moreover, cells use the energy from the proton motive force to generate ATP.
Cytosolic pH
Under physiological conditions, the cytosolic pH is slightly more acidic than the extracellular pH. However, cells must prevent further acidification of their cytosol to...
7.2K
What is Homeostasis?01:16

What is Homeostasis?

50.6K
Maintaining homeostasis requires that the body continuously maintain its internal conditions. Each physiological condition has a particular set point, from body temperature to blood pressure to levels of certain nutrients. A set point is the physiological value around which the normal range fluctuates. A normal range is a restricted set of values that is optimally healthful and stable. For example, the set point for normal human body temperature is approximately 37°C (98.6°F).
50.6K
Homeostatic Imbalance01:10

Homeostatic Imbalance

31.1K
Homeostasis is the maintenance of a stable internal environment within the body, which is crucial for the proper functioning of cells, tissues, organs, and organ systems. The body has various control mechanisms that work together to regulate various physiological parameters such as temperature, blood pressure, pH balance, and fluid balance, to name a few. These control mechanisms are based on feedback loops that can be either positive or negative.
However, sometimes these feedback loops fail,...
31.1K
Non-equilibrium in the Cell01:16

Non-equilibrium in the Cell

5.1K
An important concept in studying metabolism and energy is that of chemical equilibrium. Most chemical reactions are reversible. They can proceed in both directions, releasing energy into their environment in one direction, and absorbing it from the environment in the other direction. The same is true for the chemical reactions involved in cell metabolism, such as the breaking down and building up of proteins into and from individual amino acids, respectively. Reactants within a closed system...
5.1K
The Cell Cycle Control System01:28

The Cell Cycle Control System

4.6K
The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
4.6K
The Cell Cycle Control System02:11

The Cell Cycle Control System

13.3K
The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
13.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Midterm outcome of supra-aortic vessels reconstruction: A single-center report.

JTCVS structural and endovascular·2026
Same author

Comparison of short-term outcomes in open versus endovascular management of traumatic axillosubclavian arterial injuries in the contemporary era: a systematic review and meta-analysis.

World journal of emergency surgery : WJES·2026
Same author

Surface-Primed qPCR on Metal-Organic Frameworks for Extraction-Free Diagnostic Detection of Feline Calicivirus.

Analytical chemistry·2026
Same author

Operative and hemostatic differences between acute type A intramural hematoma and aortic dissection.

Surgery·2026
Same author

Dietary restriction mitigates cognitive impairments in a mouse model of SCA19/22.

Mechanisms of ageing and development·2026
Same author

Maternal and neonatal outcomes in Marfan syndrome: a nationwide registry.

Heart (British Cardiac Society)·2025

Related Experiment Video

Updated: Nov 22, 2025

Cytosolic Calcium Measurements in Renal Epithelial Cells by Flow Cytometry
10:24

Cytosolic Calcium Measurements in Renal Epithelial Cells by Flow Cytometry

Published on: October 28, 2014

15.5K

CISD2 maintains cellular homeostasis.

Zhao-Qing Shen1, Yi-Long Huang2, Yuan-Chi Teng1

  • 1Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan.

Biochimica Et Biophysica Acta. Molecular Cell Research
|January 10, 2021
PubMed
Summary
This summary is machine-generated.

CDGSH Iron Sulfur Domain 2 (CISD2) is a prolongevity gene influencing lifespan and healthspan. Maintaining high CISD2 levels may promote longevity, while its decline is linked to aging and diseases.

Keywords:
AgingCISD2Ca(2+) homeostasisLongevityMitochondriaMitochondria-associated membrane (MAM)Wolfram syndrome 2

More Related Videos

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism
12:38

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

Published on: December 18, 2013

6.3K
Author Spotlight: In Vitro Investigations of Circadian Rhythms in Multicellular Systems
05:44

Author Spotlight: In Vitro Investigations of Circadian Rhythms in Multicellular Systems

Published on: February 16, 2024

1.5K

Related Experiment Videos

Last Updated: Nov 22, 2025

Cytosolic Calcium Measurements in Renal Epithelial Cells by Flow Cytometry
10:24

Cytosolic Calcium Measurements in Renal Epithelial Cells by Flow Cytometry

Published on: October 28, 2014

15.5K
Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism
12:38

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

Published on: December 18, 2013

6.3K
Author Spotlight: In Vitro Investigations of Circadian Rhythms in Multicellular Systems
05:44

Author Spotlight: In Vitro Investigations of Circadian Rhythms in Multicellular Systems

Published on: February 16, 2024

1.5K

Area of Science:

  • Cellular Biology
  • Genetics
  • Aging Research

Background:

  • CDGSH Iron Sulfur Domain 2 (CISD2) is the gene responsible for Wolfram syndrome 2, an autosomal recessive disorder.
  • CISD2 protein localizes to the endoplasmic reticulum, outer mitochondrial membrane, and mitochondria-associated membrane.
  • CISD2 is vital for regulating calcium homeostasis, ER integrity, and mitochondrial function.

Purpose of the Study:

  • To review the central role of CISD2 in maintaining cellular homeostasis.
  • To discuss CISD2's function as a prolongevity gene and its impact on lifespan and healthspan.
  • To explore CISD2's involvement in aging, cell survival, and cancer development.

Main Methods:

  • Literature review of updated publications on CISD2.
  • Discussion of molecular mechanisms regulating CISD2 expression and function.
  • Analysis of CISD2's role in aging, cell death, and cancer.

Main Results:

  • CISD2 levels are key determinants of lifespan and healthspan; deficiency accelerates aging, while high levels promote longevity.
  • Exercise can stimulate CISD2 gene expression, potentially mediating its beneficial effects.
  • CISD2 is downregulated during natural aging, with potential regulatory mechanisms discussed.
  • CISD2 plays a role in cell survival and death control.
  • CISD2 exhibits dual roles in cancer development, potentially suppressing or promoting it.

Conclusions:

  • CISD2 is crucial for maintaining cellular homeostasis and plays a significant role in aging and age-related diseases.
  • Further research is needed to translate genetic evidence into pharmaceutical interventions for age-related disorders and healthy lifespan extension.