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Updated: Nov 22, 2025

Focal Laser Ablation of Prostate Cancer: An Office Procedure
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Focal Brachytherapy for Localized Prostate Cancer: Midterm Outcomes.

Minh-Hanh Ta1, Igor Nunes-Silva2, Eric Barret3

  • 1Radiotherapy Department, SNC Charlebourg, Amethyst Group, La Garenne-Colombes, France.

Practical Radiation Oncology
|January 10, 2021
PubMed
Summary

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Focal Therapy for Prostate Cancer: A Treatment Option Reserved for the Ideal Candi-date?

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Focal brachytherapy (F-BT) offers a safe and effective treatment for localized prostate cancer, showing excellent oncologic outcomes and minimal toxicity. This focal therapy adapts seed implantation to tumor specifics, preserving function for selected patients.

Area of Science:

  • Oncology
  • Radiation Oncology
  • Urology

Background:

  • Focal brachytherapy (F-BT) is a targeted treatment for localized prostate cancer.
  • It allows precise seed implantation tailored to tumor volume and location.
  • Assessing midterm outcomes is crucial for understanding its efficacy and safety.

Purpose of the Study:

  • To evaluate the oncologic, functional, and toxicity outcomes of focal brachytherapy (F-BT) in men with localized prostate cancer.
  • To determine the mid-term effectiveness of F-BT as a focal therapy approach.
  • To assess the safety profile, including urinary, sexual, and rectal toxicity.

Main Methods:

  • Retrospective study of 39 men with low- to intermediate-risk prostate cancer treated with F-BT (145 Gy prescription).

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  • Oncologic outcomes assessed via biopsies and survival rates (biochemical relapse-free, disease-free, overall).
  • Functional outcomes evaluated using International Prostate Symptom Score; toxicity assessed over mean 65-month follow-up.

    • Main Results:

    • High 5-year biochemical relapse-free survival (96.8%) and disease-free survival (79.5%).
    • No significant late urinary, sexual, or rectal toxicity observed.
    • Temporary increase in International Prostate Symptom Score at 2 months, with no significant long-term difference.

    Conclusions:

    • Focal brachytherapy (F-BT) demonstrates safety and effectiveness for selected patients with low- to intermediate-risk localized prostate cancer.
    • The technique provides favorable oncologic control with good functional preservation.
    • Salvage treatment is feasible with good tolerance if needed.