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Baseline and overtime variations of soluble adhesion molecule plasma concentrations are associated with mobility
Nicole Ziliotto1, Nicola Lamberti2, Fabio Manfredini3
1School of Medicine and Surgery, University of Milano - Bicocca, Monza, Italy; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.
Abstract:
Rehabilitative exercise outcomes and plasma concentrations of soluble adhesion molecules (sEndoglin, sE-Selectin, sL-Selectin, sICAM-1, sNCAM, sNCAM-1, sVCAM-1, sPECAM-1, sVAP-1) were evaluated in 60 severely disabled progressive multiple sclerosis (MS) patients at 4-time points. Changes of sE-Selectin, sL-Selectin, and sPECAM-1 concentrations were observed over time, and their variations were significantly correlated with rehabilitative outcome variations. Baseline sVAP-1 concentrations were able to predict functional mobility recovery. Our data suggest that the evaluation of adhesion molecules in plasma provides useful information to interpret rehabilitative exercise processes and to identify potential predictors of the rehabilitation-induced changes in mobility outcomes in MS patients.
