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Published on: August 30, 2018
Major publications in the critical care pharmacotherapy literature: 2019
Melanie Smith Condeni1, Alyson T Basting2, Patrick G Costello3
1Medical University of South Carolina, 150 Ashley Avenue, Charleston, SC 29425, USA.
Insights
This review summarizes 2019 critical care pharmacotherapy research, including guidelines and trials on sepsis, cardiac arrest, and delirium management. Key findings impact clinical practice for critically ill patients.
Area of Science:
- Critical care medicine
- Pharmacotherapy
- Evidence-based medicine
Background:
- The Critical Care Pharmacotherapy Literature Update (CCPLU) Group systematically reviews relevant literature.
- High-impact articles are identified using Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) criteria.
Purpose of the Study:
- To summarize influential meta-analyses and trials in critical care pharmacotherapy from 2019.
- To provide expert perspectives on the clinical practice impact of these publications.
Main Methods:
- Monthly screening of 36 journals for impactful articles.
- Review of 113 articles published in 2019 based on GRADE criteria.
- Focus on articles with a GRADE 1A rating, including clinical practice guidelines, meta-analyses, and original research trials.
Main Results:
- Summaries of clinical practice guidelines on polymyxins and antiarrhythmic drugs for cardiac arrest.
- Meta-analyses on antipsychotic use in delirium, stress ulcer prophylaxis (SUP), and vasoactive medications in septic shock and cardiac arrest.
- Evaluation of original research trials concerning delirium, sedation, neuromuscular blockade, SUP, anticoagulation reversal, and hemostasis.
Conclusions:
- This review offers a summary and expert opinion on key 2019 critical care pharmacotherapy publications.
- The findings highlight the clinical practice impact of influential research in the field.
Purpose:
To summarize selected meta-analyses and trials related to critical care pharmacotherapy published in 2019.
Materials And Methods:
The Critical Care Pharmacotherapy Literature Update (CCPLU) Group screened 36 journals monthly for impactful articles and reviewed 113 articles during 2019 according to Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) criteria.
Results:
Articles with a 1A grade, including three clinical practice guidelines, six meta-analyses, and five original research trials are reviewed here from those included in the monthly CCPLU. Clinical practice guidelines on the use of polymyxins and antiarrhythmic drugs in cardiac arrest as well as meta-analyses on antipsychotic use in delirium, stress ulcer prophylaxis (SUP), and vasoactive medications in septic shock and cardiac arrest were summarized. Original research trials evaluated delirium, sedation, neuromuscular blockade, SUP, anticoagulation reversal, and hemostasis.
Conclusion:
This clinical review and expert opinion provides summary and perspectives of clinical practice impact on influential critical care pharmacotherapy publications in 2019.
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