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Updated: Nov 22, 2025

Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells
Published on: October 19, 2021
The emerging role of one-carbon metabolism in T cells
Henry Kurniawan1, Takumi Kobayashi1, Dirk Brenner2
1Experimental & Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg; Immunology and Genetics, Luxembourg Centre for System Biomedicine (LCSB), University of Luxembourg, Belval, Luxembourg.
Abstract:
One-carbon metabolism (1CM) supports multiple biological functions, providing 1C units for nucleotide synthesis, epigenetic maintenance, and redox regulation. Although much has been deciphered about the relationship between disruption of 1CM and various diseases, our understanding of 1CM's involvement in the regulation of the immune system is only now evolving. In this review, we summarize key checkpoints of 1CM pathways that govern cellular activities. We also report on recent findings regarding the role of 1CM in T cells and discuss several promising avenues requiring future investigation.
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