Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute ureteric dilatation for ureteroscopy. An experimental study.

S A Boddy1, C C Nimmon, S Jones

  • 1Department of Urology, St Bartholomew's Hospital, London.

British Journal of Urology
|January 1, 1988
PubMed
Summary

Acute ureteric dilatation using three methods caused upper urinary tract issues in minipigs. Damage to the ureteric lining and inflammation persisted for weeks, indicating potential clinical concerns for ureteral procedures.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Primary Gut Lymphomas.

Leukemia & lymphoma·2016
Same author

A difficult diagnosis confounded by laboratory error: lessons learned.

Journal of clinical pathology·2009
Same author

99mTc-interleukin-2 scintigraphy in normal subjects and in patients with autoimmune thyroid diseases: a feasibility study.

European journal of nuclear medicine and molecular imaging·2008
Same author

Differential diagnosis of adnexal masses: risk of malignancy index, ultrasonography, magnetic resonance imaging, and radioimmunoscintigraphy.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society·2007
Same author

BCL2 gene abnormalities define distinct clinical subsets of follicular lymphoma.

Histopathology·2006
Same author

Radioimmunotherapy. Progress, potential and problems.

The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...·2005

Area of Science:

  • Urology
  • Nephrology
  • Experimental Medicine

Background:

  • Ureteric dilatation is a common urological procedure.
  • Understanding the impact of different dilatation methods on ureteric tissue is crucial for patient outcomes.
  • Minipigs serve as a relevant animal model for human urinary tract studies.

Purpose of the Study:

  • To compare the radiological, renographic, and histological effects of three acute ureteric dilatation methods.
  • To assess the short-term and long-term consequences of ureteric dilatation in a preclinical model.
  • To evaluate the potential for complications such as stricture formation or ischemic necrosis.

Main Methods:

  • Acute ureteric dilatation in minipigs using graded Teflon dilators, low-pressure balloon dilators, and high-pressure balloon dilators.

Related Experiment Videos

  • Ureters were dilated from 4 French (F) to 10 F.
  • Radiological, renographic, and histological assessments were performed at 24 hours and 4 weeks post-dilatation.

    • Main Results:

    • All three dilatation methods resulted in upper urinary tract dilatation and obstructive nephropathy, which persisted at 96 hours.
    • Histology at 24 hours revealed transitional epithelium destruction and ureteric wall inflammation.
    • Four weeks post-dilatation, ureters remained dilated with urothelial nests in the lamina propria and muscle coats; no ischemic necrosis or stricture was observed.

    Conclusions:

    • Acute ureteric dilatation, regardless of method, causes significant short-term and persistent histological changes in the ureter.
    • The observed urothelial damage and inflammation suggest potential long-term implications for ureteric function and integrity.
    • Further research is needed to correlate these preclinical findings with clinical outcomes and optimize dilatation techniques.