Related Experiment Video
Updated: Nov 22, 2025
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
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The migraine postdrome: Spontaneous and triggered phenotypes.
Nazia Karsan1,2, Abigail Peréz-Rodríguez1,2,3, Karthik Nagaraj1,2,4
1Headache Group, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Cephalalgia : an International Journal of Headache
|January 11, 2021
Summary
The migraine postdrome, the phase after a headache, is common and shares symptoms with the premonitory phase. Studying this postdrome phase is crucial for understanding migraine morbidity.
Area of Science:
- Neurology
- Clinical Neuroscience
- Headache Medicine
Background:
- Migraine postdrome symptoms, occurring after headache resolution, can persist for days, contributing significantly to migraine-related morbidity.
- Understanding the postdrome is essential for a comprehensive appreciation of the migraine condition.
Purpose of the Study:
- To investigate the phenotypic characteristics of the migraine postdrome.
- To compare postdrome symptoms in spontaneous versus nitroglycerin-triggered migraine attacks.
- To evaluate the consistency of postdrome symptoms between experimental and clinical migraine cohorts.
Main Methods:
- Phenotypic data on postdrome symptoms were collected from 53 subjects with migraine in an experimental setting, including spontaneous and nitroglycerin-triggered attacks.
- Data from a separate, age- and sex-matched clinical cohort of 42 migraineurs were extracted from medical records.
- Agreement analysis was used to compare phenotypes between spontaneous and triggered attacks, and between experimental and clinical groups.
Main Results:
- A postdrome was reported by 100% of subjects in the experimental group with triggered attacks and 98% with spontaneous attacks.
- In the clinical cohort, 79% reported a postdrome.
- Good agreement was observed in the experimental group for tiredness, hunger, mood changes, sensory sensitivities, and vertigo between spontaneous and triggered attacks, with similar premonitory and postdrome phenotypes.
Conclusions:
- The migraine postdrome is a frequent occurrence and exhibits symptom overlap with the premonitory phase.
- The nitroglycerin model and migraine abortive medications offer viable experimental approaches for studying the postdrome.
- Systematic symptom inquiry and collateral histories from observers can improve the capture and understanding of postdrome symptoms, aiding research into migraine mediation, abortion, and neurobiology.
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