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Magnetic Resonance-Guided Stereotaxy for Infusions to the Pig Brain
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A single-centre study of frame-based stereotactic brain biopsies.
Anna Pennlund1, Asgeir S Jakola2,3, Thomas Skoglund2,3
1Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
British Journal of Neurosurgery
|January 11, 2021
Summary
Frame-based stereotactic biopsy shows high diagnostic yield but suboptimal concordance with imaging. This method confirms diagnoses with low complication rates, though histopathological undergrading is noted.
Area of Science:
- Neurology
- Radiology
- Pathology
Background:
- Accurate preoperative diagnosis is crucial for guiding treatment decisions in neurological conditions.
- Image-based diagnoses can sometimes differ from definitive histopathological findings.
Purpose of the Study:
- To assess the agreement between image-based and tissue-based diagnoses using frame-based stereotactic biopsy.
- To evaluate the diagnostic yield, accuracy, and complication rates of this biopsy technique.
Main Methods:
- Review of medical records for 125 frame-based stereotactic biopsy procedures (2000-2017).
- Comparison of preoperative radiological diagnoses with postoperative histopathological diagnoses.
- Analysis of diagnostic concordance, yield, morbidity, and mortality.
Main Results:
- Concordance between image-based and histopathological diagnoses ranged from 53.3% to 87.5%.
- Specific concordance for tumor entity and WHO grade was 54.6%.
- Diagnostic yield was high (95.2%), with overall morbidity at 10.4% and mortality at 0.8%.
Conclusions:
- Frame-based stereotactic biopsy offers a high diagnostic yield with a low risk of significant complications.
- Suboptimal concordance between radiological and histopathological diagnoses was observed.
- A trend towards histopathological undergrading suggests potential limitations in diagnostic accuracy.
