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Updated: Nov 22, 2025
Magnetic Resonance-Guided Stereotaxy for Infusions to the Pig Brain
Published on: March 31, 2023
A single-centre study of frame-based stereotactic brain biopsies
Anna Pennlund1, Asgeir S Jakola2,3, Thomas Skoglund2,3
1Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Objective:
We aimed to evaluate the concordance between the image-based and the tissue-based diagnosis using frame-based stereotactic biopsy.
Materials And Methods:
Medical records of biopsy procedures from 2000 to 2017 were reviewed. The radiologists' preoperative reports, biopsy procedures and postoperative histopathological diagnoses were retrieved. We compared the preoperative image-based diagnosis with the final histopathological diagnosis.
Results:
We identified 125 biopsy procedures performed in 123 patients. The concordance between image-based and histopathological diagnoses varied between 53.3% and 87.5%. The concordance of diagnosis concerning both tumor entity (i.e. cell type) and WHO grade was 54.6%. The diagnostic yield was 95.2%. There was overall morbidity of 10.4%, and a mortality rate of 0.8%. Minor complications occurred in 4.0% of the cases, while clinically significant complications occurred in 6.4% of the cases.
Conclusions:
There was suboptimal concordance between radiological and histopathological diagnosis. Also, there was a tendency of histopathological undergrading. We confirm that frame-based stereotactic biopsies have a high diagnostic yield and a low rate of clinically significant complications and mortality.
