Necropsy protocol for newborn mice.

Area of Science:

• Laboratory animal science
• Veterinary pathology
• Animal welfare

Background:

• Neonatal mortality rates are a significant concern in laboratory mouse breeding facilities.
• The underlying causes of high pup mortality are frequently not well understood, hindering effective intervention strategies.

Purpose of the Study:

• To present a standardized necropsy protocol specifically designed for neonatal laboratory mice.
• To provide a practical and easily applicable method for animal technicians to gain insights into pup mortality.

Main Methods:

• Development of a detailed necropsy protocol tailored for small neonatal mouse cadavers.
• Emphasis on systematic examination of gross pathological findings relevant to neonatal death.

Main Results:

• The protocol facilitates the identification of potential causes of neonatal mortality in mice.
• It serves as an accessible tool for routine use by animal care staff.

Conclusions:

• Implementing this necropsy protocol can enhance the understanding of neonatal mortality in mouse colonies.
• This systematic approach contributes to improved animal welfare and breeding colony health.