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Related Experiment Video

Updated: Nov 22, 2025

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

Published on: January 27, 2019

Necropsy protocol for newborn mice.

Sara Capas-Peneda^1,2, Gabriela Munhoz Morello^1,2, Sofia Lamas^2,3

¹Laboratory Animal Science, IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Portugal.

Laboratory Animals

|January 11, 2021

Summary

This summary is machine-generated.

High neonatal mortality in lab mice is a problem. A new necropsy protocol for neonatal mice can help animal technicians easily identify causes of death.

Keywords:

Perinatal mortality mouse necropsy pathology physiology

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Last Updated: Nov 22, 2025

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Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

Area of Science:

Laboratory animal science
Veterinary pathology
Animal welfare

Background:

Neonatal mortality rates are a significant concern in laboratory mouse breeding facilities.
The underlying causes of high pup mortality are frequently not well understood, hindering effective intervention strategies.

Purpose of the Study:

To present a standardized necropsy protocol specifically designed for neonatal laboratory mice.
To provide a practical and easily applicable method for animal technicians to gain insights into pup mortality.

Main Methods:

Development of a detailed necropsy protocol tailored for small neonatal mouse cadavers.
Emphasis on systematic examination of gross pathological findings relevant to neonatal death.

Main Results:

The protocol facilitates the identification of potential causes of neonatal mortality in mice.
It serves as an accessible tool for routine use by animal care staff.

Conclusions:

Implementing this necropsy protocol can enhance the understanding of neonatal mortality in mouse colonies.
This systematic approach contributes to improved animal welfare and breeding colony health.