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Published on: October 24, 2019
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[Computed Tomography Imaging Features of IgG4-related Nephropathy]
Zhe Wu1,2, Yi Tang1, Guo Lu Jiang1
1Department of Radiology, Fushun Central Hospital, Fushun, Liaoning 113006,China.
Summary
Computed tomography (CT) imaging of IgG4-related kidney disease (IgG4-RKD) reveals distinct features. These findings help differentiate IgG4-RKD from renal tumors, potentially avoiding unnecessary surgeries.
Area of Science:
- Radiology
- Nephrology
- Immunology
Background:
- Immunoglobulin G4-related kidney disease (IgG4-RKD) presents diagnostic challenges.
- Distinguishing IgG4-RKD from renal malignancies is crucial for appropriate patient management.
Purpose of the Study:
- To elucidate the characteristic computed tomography (CT) imaging features of IgG4-RKD.
- To identify CT findings that aid in differentiating IgG4-RKD from other renal pathologies, particularly malignant tumors.
Main Methods:
- Retrospective analysis of clinicopathological and CT imaging data from 36 IgG4-RKD patients.
- Inclusion criteria covered various presentations, including renal parenchyma, renal pelvis involvement, and single or multiple lesions.
Main Results:
- IgG4-RKD demonstrated specific CT features, including clear boundaries and continuous progressive enhancement.
- Absence of common malignant tumor signs like hydronephrosis and hematuria was noted, despite renal pelvis involvement.
- Lesions showed no liquefaction, necrosis, cystic degeneration, or calcification; renal pelvis involvement did not invade surrounding parenchyma.
Conclusions:
- CT imaging findings in IgG4-RKD can mimic those of renal malignant tumors.
- Integration of CT findings with clinicopathological data and serum IgG4 levels enables accurate diagnosis.
- This approach can prevent unnecessary surgical interventions for IgG4-RKD.
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