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Updated: Nov 22, 2025

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
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A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice

Published on: November 24, 2020

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[Advances in Post-translational Modifications and Endometriosis]

Jing Wen Zhu1, Qing Xue1

  • 1Department of Gynecology and Obstetrics,Peking University First Hospital,Beijing 100034,China.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
|January 11, 2021
PubMed

Insights

Post-translational modifications (PTMs) influence protein function and disease. This review explores how PTMs contribute to endometriosis development and potential therapeutic strategies.

Area of Science:

  • Molecular Biology
  • Biochemistry
  • Gynecology

Background:

  • Proteins perform vital functions through post-translational modifications (PTMs), including phosphorylation, acetylation, ubiquitination, glycosylation, and methylation.
  • These modifications alter protein functions and are implicated in various diseases.
  • Endometriosis, a prevalent condition in women, has unclear molecular underpinnings, but PTMs are increasingly recognized as potential contributors.

Purpose of the Study:

  • To review the current understanding of post-translational modifications in endometriosis.
  • To explore the roles of PTMs in the pathogenesis and progression of endometriosis.
  • To discuss potential therapeutic interventions targeting PTMs for endometriosis treatment.

Main Methods:

  • Literature review of recent studies on PTMs and endometriosis.
  • Analysis of the molecular mechanisms linking PTMs to endometriosis.
  • Synthesis of information on PTM-related therapeutic strategies for endometriosis.

Main Results:

  • PTMs significantly impact protein function and are involved in the development of various diseases.
  • Evidence suggests PTMs play a role in the occurrence and progression of endometriosis.
  • Specific PTMs are being investigated for their involvement in endometriosis pathogenesis.

Conclusions:

  • Post-translational modifications are critical regulators of cellular processes and disease development.
  • PTMs are implicated in the molecular mechanisms underlying endometriosis.
  • Targeting PTMs represents a promising avenue for future endometriosis therapies.
Keywords:
endometriosispathogenesispost-translational modifications

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