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Persistent chromosome damage induced by localized radiotherapy for lymphoma
A L Zaslav1, J Stamberg, A Shende
1Division of Human Genetics, Schneider Children's Hospital, Long Island Jewish Medical Center, New Hyde Park, NY 11042.
Cancer Genetics and Cytogenetics
|February 1, 1988
Summary
Chromosomal abnormalities were found in lymph node cells of a non-Hodgkin lymphoma patient post-treatment, distinct from normal blood and bone marrow cells. These radiation-induced changes may increase the risk of future cancers.
Area of Science:
- Cytogenetics
- Radiation Oncology
- Cancer Biology
Background:
- Investigating chromosomal aberrations in non-Hodgkin lymphoma (NHL) patients following treatment.
- Assessing the impact of chemotherapy and therapeutic irradiation on patient lymph node cells.
Observation:
- Established fibroblast culture from a lymph node biopsy 9 months post-chemotherapy and irradiation.
- Compared lymph node cells with blood and bone marrow cells from the same patient.
Findings:
- All lymph node cells exhibited chromosomal abnormalities, unlike normal blood and bone marrow cells.
- Multiple structural abnormalities including translocations, deletions, and inversions were observed.
- Centromeric breakpoints were in excess, but numerical abnormalities were absent.
Implications:
- Chromosome abnormalities were linked to radiation exposure, not directly to the lymphoma itself.
- These acquired genetic changes in lymph stroma may represent a risk factor for secondary malignancies.