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A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
Published on: October 5, 2015
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[Assessment of body composition during pulmonary tuberculosis]
1Service de pneumologie allergologie (Unité de recherche LR18SP02), faculté de Médecine de Tunis, université de Tunis El Manar, CHU La Rabta, Tunis, Tunisie.
Revue Des Maladies Respiratoires
|January 11, 2021
Summary
Bioelectrical impedance analysis (BIA) better assesses body composition in tuberculosis (TB) patients than body mass index (BMI). Malnutrition is common and linked to TB severity, necessitating nutritional support alongside treatment.
Area of Science:
- Nutritional assessment in infectious diseases
- Body composition analysis in clinical practice
Background:
- Body mass index (BMI) is a standard but limited tool for assessing nutritional status in active tuberculosis (TB).
- BMI does not adequately capture changes in body composition, crucial for understanding disease impact.
Purpose of the Study:
- To evaluate the utility of bioelectrical impedance analysis (BIA) in assessing body composition in TB patients.
- To compare BIA's effectiveness against BMI for nutritional status evaluation in TB.
- To identify factors associated with body composition changes during TB.
Main Methods:
- Cross-sectional study involving 95 active TB patients in Tunis, Tunisia.
- Nutritional assessment included Body Mass Index (BMI) measurements.
- Body composition analyzed using Bioelectrical Impedance Analysis (BIA), defining malnutrition by lean mass index (LMI).
Main Results:
- 38% of TB patients exhibited undernutrition based on LMI.
- Declines in LMI were significantly associated with increased TB severity.
- While BMI and LMI correlated, BMI alone missed lean mass loss in 10% of patients.
Conclusions:
- Undernutrition is prevalent in active TB and correlates with disease severity.
- Nutritional management is a critical component of TB patient care, complementing anti-tuberculosis drugs.
- BIA offers a more comprehensive assessment of body composition than BMI in TB patients.
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