Related Experiment Video
Updated: Nov 22, 2025

Lethality Bioassay Using Artemia salina L.
Published on: October 11, 2022
Lethality-Associated Factors in Deliberate Self-Poisoning
In Young Choi1, Sun-Young Kim2, Jhin Goo Chang1
1Department of Psychiatry, Myongji Hospital, Hanyang University College of Medicine, Goyang, Korea.
Deliberate self-poisoning (DSP) is a serious suicide method. Factors like male sex, older age, and herbicide use increase DSP lethality, while denying intent decreases it.
Area of Science:
- Medical Toxicology
- Emergency Medicine
- Psychiatry
Background:
- Deliberate self-poisoning (DSP) is a prevalent and potentially fatal method of suicide.
- Understanding factors influencing DSP lethality is crucial for clinical intervention.
Purpose of the Study:
- To investigate factors associated with the lethality of deliberate self-poisoning (DSP).
- To characterize the adolescent group within DSP cases.
Main Methods:
- Retrospective study of 491 patients at an academic hospital's emergency medical center (2015-2018).
- Analysis of sociodemographic factors, clinical variables, and psychiatric treatment.
- Categorization into four groups using the risk-rescue rating scale.
Main Results:
- High lethality in DSP was linked to male sex, older age, admitted suicidal intent, and herbicide use.
- Logistic regression identified significant associations: female sex (OR=0.50), non-psychiatric drugs (OTC: OR=2.49, herbicide: OR=8.65), and denial of suicide intent (OR=0.28).
Conclusions:
- Clinical factors significantly correlate with the high lethality of deliberate self-poisoning (DSP).
- Emphasizes the need for thorough examination and care for patients presenting with DSP.
More Related Videos
11:14Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry
Published on: October 2, 2016
07:40A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
Published on: May 27, 2021
Related Concept Videos
Prevention of Further Absorption of Poison
Anticholinesterase Agents: Poisoning and Treatment
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
Enhanced Elimination of Poison
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
Types of Toxins
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Antidotes
Specific antidotes operate by inhibiting the enzymes that control biochemical pathways, reducing the production of harmful metabolites.
An example of an antidote is atropine, which counteracts the detrimental effects of cholinesterase inhibitors. It achieves this by deactivating muscarinic receptors,...
Toxic Reactions: Overview
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...