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Association of Plasma C1q/TNF-Related Protein 3 (CTRP3) in Patients with Atrial Fibrillation

Liwen Chen1,2,3,4, Shuwang Liu1,2,3,4, Wei Xu1,2,3,4

  • 1Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, 49 Huayuan-Bei Road, Haidian District, Beijing 100191, China.

Mediators of Inflammation
|January 11, 2021
PubMed

Insights

Lower plasma levels of Complement C1q tumor necrosis factor-related protein 3 (CTRP3) are linked to atrial fibrillation (AF). This study found reduced CTRP3 in AF patients and correlated it with AF presence and recurrence.

Area of Science:

  • Cardiology
  • Endocrinology
  • Biochemistry

Background:

  • Atrial fibrillation (AF) is a common arrhythmia linked to cardiac remodeling.
  • Complement C1q tumor necrosis factor-related protein 3 (CTRP3), an adipokine, is associated with metabolic and cardiovascular diseases.
  • The relationship between CTRP3 levels and AF remains unclear.

Purpose of the Study:

  • To investigate the association between plasma CTRP3 concentrations and the presence of AF.
  • To explore the correlation of CTRP3 levels with AF subtypes and recurrence post-ablation.

Main Methods:

  • Cross-sectional study comparing 75 AF patients undergoing catheter ablation with 47 control subjects in sinus rhythm.
  • Plasma CTRP3 concentrations were measured using ELISA.
  • Multivariate regression analysis was employed to identify independent correlations.

Main Results:

  • Plasma CTRP3 levels were significantly lower in AF patients compared to controls (366.9 ± 105.2 vs. 429.1 ± 100.1 ng/ml, p=0.002).
  • Persistent AF patients showed lower CTRP3 than paroxysmal AF patients (328.3 ± 83.3 vs. 380.0 ± 109.2 ng/ml, p=0.037).
  • AF recurrence group had lower CTRP3 levels than the non-recurrence group (337.9 ± 77.3 vs. 386.6 ± 108.1 ng/ml, p=0.045).

Conclusions:

  • Plasma CTRP3 concentrations are independently correlated with the presence of AF.
  • Lower CTRP3 levels may indicate a higher risk of AF and recurrence after catheter ablation.

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