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Related Concept Videos

Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

862
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
862
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

452
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
452
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

180
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
180
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

456
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
456

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Updated: Nov 22, 2025

An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation
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Experimental Acute Pancreatitis Models: History, Current Status, and Role in Translational Research.

Xinmin Yang1, Linbo Yao1, Xianghui Fu2

  • 1Department of Integrated Traditional Chinese Medicine and Western Medicine, Sichuan Provincial Pancreatitis Center and West China-Liverpool Biomedical Research Center, West China Hospital, Sichuan University, Chengdu, China.

Frontiers in Physiology
|January 11, 2021
PubMed
Summary

Research on acute pancreatitis, a severe inflammatory condition, heavily relies on animal models due to human study challenges. This review explores various animal models, aiding understanding and new therapy development for acute pancreatitis.

Keywords:
acute pancreatitisanimal modelspancreatic acinar cellspancreatic ductal cellspancreatic stellate cellstranslational research

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Area of Science:

  • Gastroenterology and Hepatology
  • Inflammatory Diseases
  • Translational Medicine

Background:

  • Acute pancreatitis presents significant morbidity and mortality.
  • Current lack of specific treatments necessitates further research.
  • Studying the human pancreas is challenging due to its location and disease unpredictability.

Approach:

  • This review synthesizes historical and current animal models of acute pancreatitis.
  • It analyzes the characteristics and applications of various models.
  • Key studies utilizing these models are identified to illustrate their impact.

Key Points:

  • Animal models have been instrumental in advancing the understanding of acute pancreatitis pathogenesis for over a century.
  • Different models offer unique insights into specific aspects of the disease.
  • The review highlights the critical role of these models in preclinical research.

Conclusions:

  • Animal models are indispensable tools for acute pancreatitis research.
  • Continued development and application of animal models are vital for discovering novel therapeutic strategies.
  • Understanding model limitations and strengths is key for effective translational research.