Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

3.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
3.6K
Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

1.5K
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
1.5K
T Cell Types and Functions01:24

T Cell Types and Functions

1.8K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.8K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

1.5K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
1.5K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

976
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
976

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deleterious germline CARD11 gain-of-function variants alter human B-cell and CD4+ T-cell differentiation and function.

Clinical and experimental immunology·2026
Same author

A novel case of autosomal recessive CARD11 loss-of-function underlying impaired antiviral immunity and a review of literature.

Clinical & translational immunology·2026
Same author

PD-1 protects expanding human T cells from premature restimulation-induced cell death by modulating TCR and CD28 signaling.

Cell death & disease·2026
Same author

B-cell lymphocytosis and reprogramming due to biallelic CARD11 mutations.

The Journal of allergy and clinical immunology·2025
Same author

Hematopoietic stem cell gene therapy for the treatment of X-linked agammaglobulinemia.

Molecular therapy. Methods & clinical development·2025
Same author

Characterization of novel and recurrent <i>SPTLC2</i> variants in childhood-onset amyotrophic lateral sclerosis: Insights into sphingolipid dysregulation.

Journal of neuromuscular diseases·2025

Related Experiment Video

Updated: Nov 22, 2025

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System
10:25

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

Published on: September 20, 2019

7.2K

ORMDL3 and Asthma: Linking Sphingolipid Regulation to Altered T Cell Function.

Christopher R Luthers1, Teresa M Dunn1,2, Andrew L Snow1

  • 1Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.

Frontiers in Immunology
|January 11, 2021
PubMed
Summary
This summary is machine-generated.

Increased Orosomucoid like 3 (ORMDL3) expression in CD4+ T cells drives asthma pathogenesis by altering sphingolipid metabolism and T cell function. This highlights ORMDL3 as a key factor in allergic asthma development.

Keywords:
T cellallergic inflammationasthmaorosomucoid like sphingolipid biosynthesis regulator 3sphingolipids

More Related Videos

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

7.9K
Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

633

Related Experiment Videos

Last Updated: Nov 22, 2025

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System
10:25

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

Published on: September 20, 2019

7.2K
Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

7.9K
Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

633

Area of Science:

  • Immunology
  • Cell Biology
  • Genetics

Background:

  • Orosomucoid like 3 (ORMDL3) is an ER-resident protein regulating sphingolipid biosynthesis.
  • Genome-wide association studies linked ORMDL3 expression to asthma susceptibility.

Purpose of the Study:

  • To review evidence linking ORMDL3 expression in CD4+ T lymphocytes to asthma pathogenesis.
  • To explore the role of sphingolipid modulation in T cells.

Main Methods:

  • Review of existing literature and genetic association studies.
  • Analysis of ORMDL3 function in CD4+ T cell differentiation and immunity.

Main Results:

  • Heightened ORMDL3 expression in CD4+ T cells is associated with asthma.
  • Altered sphingolipid metabolism in T cells may mediate these effects.
  • ORMDL3 influences T cell differentiation and function, contributing to asthma.

Conclusions:

  • ORMDL3 in CD4+ T cells is a significant factor in asthma pathogenesis.
  • Sphingolipid modulation is a potential mechanism underlying ORMDL3's role in asthma.
  • Further research is needed to fully elucidate this pathway.