Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

In Vitro Drug Release Testing: Overview, Development and Validation01:10

In Vitro Drug Release Testing: Overview, Development and Validation

117
In vitro dissolution and drug release tests assess how quickly and how much of a drug is released from its dosage form into an aqueous medium under standardized laboratory conditions. These tests are essential tools in pharmaceutical development and quality assurance, offering insight into the drug's performance before clinical use.During formulation development, dissolution testing identifies incomplete or inconsistent drug release issues. It also supports decisions on selecting the optimal...
117
In-vitro Mutagenesis01:16

In-vitro Mutagenesis

15.7K
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
15.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Selective Bidentate Coordination Reconstructs Residual PbI<sub>2</sub> to Homogenize Interfacial Energetics in Perovskite Solar Cells.

Journal of the American Chemical Society·2026
Same author

A Transparent, Microfluidic Lab On A Chip For Multi-Modal Cell Culture Monitoring For Neurotoxicity Research.

IEEE transactions on nanobioscience·2026
Same author

Dehydration/1,6-addition-based Site-specific Bioconjugation Unveils Norepinephrinylation as a Widespread Post-translational Modification in the Cellular Proteome.

bioRxiv : the preprint server for biology·2026
Same author

Perfluorooctanoic acid exposure disrupts gut microbiota and aggravates experimental colitis.

Environmental pollution (Barking, Essex : 1987)·2026
Same author

Embryonic lead (Pb) contact impairs lipid, oxidative, and behavioral markers in zebrafish across multiple generations.

Environmental research·2026
Same author

Allelic Analysis of <i>smc-6</i> Reveals Domain-Specific Roles in DNA Repair in <i>Caenorhabditis elegans</i>.

International journal of molecular sciences·2026

Related Experiment Video

Updated: Nov 22, 2025

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
17:28

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Published on: June 17, 2015

12.9K

Review: In vitro Cell Platform for Understanding Developmental Toxicity.

Junkai Xie1, Kyle Wettschurack1, Chongli Yuan1,2

  • 1Davidson School of Chemical Engineering, Purdue University, West Lafayette, IN, United States.

Frontiers in Genetics
|January 11, 2021
PubMed
Summary

Developmental toxicity impacts long-term health, but tracking these effects is challenging. Induced pluripotent stem cell (iPSC)-derived neuronal models and neurodegenerative disease (ND) biomarkers offer new ways to study developmental neurotoxicity.

Keywords:
IPSCdevelopmental exposureepigeneticsneurodegenerative diseaseorganoid

More Related Videos

Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells
05:45

Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells

Published on: October 10, 2025

216
Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing
09:02

Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing

Published on: June 9, 2017

23.9K

Related Experiment Videos

Last Updated: Nov 22, 2025

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
17:28

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Published on: June 17, 2015

12.9K
Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells
05:45

Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells

Published on: October 10, 2025

216
Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing
09:02

Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing

Published on: June 9, 2017

23.9K

Area of Science:

  • Neuroscience
  • Toxicology
  • Stem Cell Biology

Background:

  • Developmental toxicity is linked to long-term health issues, including neurodegenerative diseases (ND).
  • Current models struggle to track longitudinal changes caused by developmental toxicity.
  • Induced pluripotent stem cells (iPSCs) enable advanced in vitro neuronal models.

Purpose of the Study:

  • To review progress in iPSC-derived neuronal cultures for studying developmental toxicity.
  • To highlight advancements in neurodegenerative disease (ND) biomarker detection.
  • To explore novel tools for understanding neurotoxicity from developmental exposure.

Main Methods:

  • Utilizing induced pluripotent stem cell (iPSC) technology to create neuronal cultures.
  • Leveraging recent developments in detecting neurodegenerative disease (ND) biomarkers.
  • Reviewing existing literature on iPSC-derived neuronal models and ND markers.

Main Results:

  • iPSC-derived neuronal cultures provide complex and functionally active in vitro models.
  • Progress in ND biomarker detection enhances the study of neurotoxicity.
  • A combination of iPSC models and biomarker detection offers promising tools.

Conclusions:

  • iPSC-derived neuronal models are valuable for investigating developmental toxicity.
  • Advancements in ND biomarkers improve the understanding of neurotoxic effects.
  • These tools are crucial for assessing long-term health risks from developmental exposures.