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Updated: Nov 22, 2025
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Published on: April 17, 2021
Nephroprotective Effect of Mesenchymal Stem Cell-Based Therapy of Kidney Disease Induced by Toxicants
Shujun Lin1, Wenshan Lin1, Chunling Liao1
1Department of Nephrology, The Second Affiliated Hospital, Shantou University Medical College, 515041 Shantou, China.
Background:
Renal damage caused by drug toxicity is becoming increasingly common in the clinic. Preventing and treating kidney damage caused by drug toxicity are essential to maintain patient health and reduce the social and economic burden. In this study, we performed a meta-analysis to assess the nephroprotective effect of mesenchymal stem cells (MSCs) in the treatment of kidney disease induced by toxicants.
Methods:
The Cochrane Library, Embase, ISI Web of Science, and PubMed databases were searched up to December 31, 2019, to identify studies and extract data to assess the efficacy of MSCs treatment of kidney disease induced by toxicants using Cochrane Review Manager Version 5.3. A total of 27 studies were eligible and selected for this meta-analysis.
Results:
The results showed that a difference in serum creatinine levels between the MSC treatment group and control group was observed for 2, 4, 5, 6-8, 10-15, 28-30, and ≥42 days (2 days: WMD = -0.88, 95% CI: -1.34, -0.42, P = 0.0002; 4 days: WMD = -0.74, 95% CI: -0.95, -0.54, P < 0.00001; 5 days: WMD = -0.46, 95% CI: -0.67, -0.25, P < 0.0001; 6-8 days: WMD = -0.55, 95% CI: -0.84, -0.26, P = 0.0002; 10-15 days: WMD = -0.37, 95% CI: -0.53, -0.20, P < 0.0001; 28-30 days: WMD = -0.53, 95% CI: -1.04, -0.02, P = 0.04; ≥42 days: WMD = -0.22, 95% CI: -0.39, -0.06, P = 0.007). Furthermore, a difference in blood urea nitrogen levels between the MSC treatment group and control group was observed for 2-3, 4-5, 6-8, and ≥28 days. The results also indicate that MSC treatment alleviated inflammatory cells, necrotic tubules, regenerative tubules, and renal interstitial fibrosis in kidney disease induced by toxicants.
Conclusion:
MSCs may be a promising therapeutic agent for kidney disease induced by toxicants.
Insights
Mesenchymal stem cells (MSCs) show promise in treating drug-induced kidney damage. This meta-analysis found MSCs significantly reduced creatinine and BUN levels, alleviating kidney injury markers.
Area of Science:
- Nephrology
- Regenerative Medicine
- Pharmacology
Background:
- Drug-induced nephrotoxicity is a growing clinical concern, necessitating effective prevention and treatment strategies.
- Kidney damage from toxicants poses a significant health burden, highlighting the need for therapeutic interventions.
- Mesenchymal stem cells (MSCs) are being investigated for their potential in treating various conditions, including kidney disease.
Purpose of the Study:
- To conduct a meta-analysis assessing the nephroprotective effects of mesenchymal stem cells (MSCs) in toxicant-induced kidney disease.
- To evaluate the efficacy of MSCs in mitigating biochemical and histological markers of kidney damage.
- To determine the therapeutic potential of MSCs as a treatment for drug-induced renal injury.
Main Methods:
- A systematic literature search was performed across Cochrane Library, Embase, Web of Science, and PubMed up to December 31, 2019.
- Data from 27 eligible studies were extracted and analyzed using Cochrane Review Manager Version 5.3.
- The meta-analysis focused on comparing serum creatinine and blood urea nitrogen levels, as well as histological outcomes, between MSC treatment and control groups.
Main Results:
- MSC treatment significantly reduced serum creatinine levels at multiple time points (2, 4, 5, 6-8, 10-15, 28-30, and ≥42 days) compared to controls.
- Significant differences in blood urea nitrogen levels were observed between MSC-treated and control groups at various intervals (2-3, 4-5, 6-8, and ≥28 days).
- MSC therapy demonstrated efficacy in alleviating inflammatory cell infiltration, necrotic tubules, and renal interstitial fibrosis in toxicant-induced kidney injury.
Conclusions:
- Mesenchymal stem cells (MSCs) exhibit significant nephroprotective effects in the context of toxicant-induced kidney disease.
- MSC treatment offers a promising therapeutic strategy for managing and potentially reversing kidney damage caused by drug toxicity.
- Further research into MSC-based therapies is warranted for clinical application in preventing and treating drug-induced nephrotoxicity.
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