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Intact parathyrin in postmenopausal women
L J Sokoll1, F D Morrow, D M Quirbach
1Calcium and Bone Metabolism Laboratory, USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111.
Clinical Chemistry
|February 1, 1988
Summary
This study established a reference range for intact parathyrin (parathyroid hormone, PTH) in healthy postmenopausal women. The findings highlight the assay
Area of Science:
- Endocrinology
- Clinical Chemistry
Background:
- Establishing reference ranges for intact parathyrin (parathyroid hormone, PTH) is crucial for understanding calcium homeostasis.
- Previous assays lacked the sensitivity to accurately assess PTH levels in healthy populations.
Purpose of the Study:
- To determine the reference range for intact parathyrin in healthy postmenopausal women.
- To evaluate the correlation between intact PTH, age, and serum calcium levels.
Main Methods:
- Intact parathyrin was measured in 245 healthy postmenopausal women (ages 42-75) using the Allegro Intact PTH Kit.
- Serum from a subset (n=120) was also assayed for mid-molecule PTH.
- Serum calcium concentrations were measured concurrently.
Main Results:
- The mean intact PTH concentration was 32 ng/L (95% CI: 14-60 ng/L).
- Intact PTH levels were not normally distributed, unlike calcium concentrations.
- A significant negative correlation was found between serum calcium and intact PTH.
Conclusions:
- The intact PTH assay provides a sensitive tool for assessing calcium homeostasis in healthy individuals.
- The established reference range aids in the interpretation of PTH levels in postmenopausal women.
- The assay's sensitivity is beneficial for research on calcium metabolism.