Susac Syndrome and Pregnancy

Area of Science:

• Neurology
• Immunology
• Obstetrics

Background:

• Susac syndrome (SuS) is a rare, poorly characterized autoimmune disorder affecting the brain, retina, and cochlea.
• Management of SuS during pregnancy presents unique challenges due to potential risks to both mother and fetus.

Observation:

• A 31-year-old pregnant female was diagnosed with Susac syndrome.
• The patient presented with symptoms indicative of SuS affecting multiple organ systems.

Findings:

• Successful management of Susac syndrome was achieved through a combination of intravenous methylprednisolone, oral prednisone, and intravenous immunoglobulin (IVIg).
• The pregnancy was managed until 36 weeks of gestation with minimal disease burden observed in both the mother and the newborn.
• Treatment focused on immunosuppression tailored for pregnant patients.

Implications:

• This case highlights the feasibility of managing Susac syndrome during pregnancy with appropriate therapeutic strategies.
• A multidisciplinary approach involving neurology and maternal-fetal medicine is crucial for optimal outcomes.
• Further research into immunosuppressive therapies for Susac syndrome in pregnant populations is warranted.