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De novo 3q/7q translocation and associated interstitial 7q35 deletion
J P Fryns1, A Kleczkowska, H van den Berghe
1Centre for Human Genetics, University of Leuven, Belgium.
Clinical Genetics
|January 1, 1988
Abstract:
In the present report we describe a severely mentally retarded and dysmorphic female child with a de novo 3q/7q reciprocal translocation and loss of band 7q35. This finding supports the hypothesis that the occurrence of mental retardation and/or congenital malformations in de novo autosomal reciprocal translocation may be due to the loss of a small amount of chromatin material during this chromosomal rearrangement.