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miRNA-451a and miRNA-125a Expression Levels in Ankylosing Spondylitis: Impact on Disease Diagnosis, Prognosis, and
Dina Salem Fotoh1, Rasha Ibrahim Noreldin2, Mohamed Soliman Rizk3
1Physical Medicine, Rheumatology and Rehabilitation Department, Faculty of Medicine, Menoufia University, Egypt.
Background:
Early diagnosis of ankylosing spondylitis (AS) is yet not elucidated, with a potential diagnostic glance of microRNAs (miRNAs).
Aim:
Study the expression profile of miRNA-451a and miRNA-125a in AS patients and their impact on disease activity and prognosis.
Methods:
A cross-sectional study included 55 AS patients diagnosed according to modified New York criteria in 1984 with 55 matched healthy controls. History, clinical examination, and disease activity assessment with Bath ankylosing spondylitis disease activity index (BASDAI) were done. Full laboratory and radiological assessment along with expression profile of m iRNA-451a and miRNA-125a were tabulated and analyzed.
Results:
Higher expression levels of miRNA-125a and lower of miRNA-451a in AS patients compared to controls. Furthermore, miRNA-125a expression was high in active AS patients compared to inactive patients and controls (7.0 ± 3.4 vs. 4.1 ± 2.1 vs. 2.6 ± 0.6, p < 0.001, respectively). miRNA-451a was significantly lower in active AS patients compared to inactive patients and controls (2.2 ± 1.1 vs. 4.1 ± 2.3 vs. 7.1 ± 4.5, respectively). Both miRNAs (miRNA-125a and miRNA-451a) had evident accuracy for AS diagnosis with areas under the curve (AUC) of 0.788 and 0.802, respectively. miRNA-125a had potential impact on AS activity with AUC of 0.777. Plasma levels of both miRNAs were able to distinguish AS patients with structural damage with AUCs 0.775 and 0.692, respectively.
Conclusions:
Both miRNA-451a and miRNA-125a were found to be of great value as sensitive noninvasive diagnostic, prognostic, and disease burden biomarker of AS patients in Egypt with suggested further studies for future therapeutic implications.
Insights
MicroRNA-125a and microRNA-451a show promise as noninvasive biomarkers for diagnosing ankylosing spondylitis (AS) and assessing disease activity. These microRNAs (miRNAs) can help identify AS patients and predict disease progression.
Area of Science:
- Biochemistry
- Genetics
- Immunology
Background:
- Early diagnosis of ankylosing spondylitis (AS) remains challenging.
- MicroRNAs (miRNAs) are emerging as potential diagnostic markers for AS.
Purpose of the Study:
- To investigate the expression profiles of miRNA-451a and miRNA-125a in AS patients.
- To evaluate the impact of these miRNAs on AS disease activity and prognosis.
Main Methods:
- A cross-sectional study involving 55 AS patients and 55 healthy controls.
- Assessment of clinical data, disease activity (BASDAI), laboratory tests, and radiological findings.
- Analysis of miRNA-451a and miRNA-125a expression levels.
Main Results:
- AS patients exhibited higher miRNA-125a and lower miRNA-451a expression compared to controls.
- Elevated miRNA-125a and decreased miRNA-451a levels correlated with active AS.
- Both miRNAs demonstrated diagnostic accuracy for AS (AUCs 0.788 and 0.802) and prediction of structural damage.
Conclusions:
- miRNA-451a and miRNA-125a are valuable sensitive, noninvasive biomarkers for AS diagnosis and prognosis.
- These miRNAs can serve as indicators of disease burden in AS patients.
- Further research is recommended for potential therapeutic applications.
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