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Task Specific Tremor Subsequently Developing into Parkinson's Disease: Case Series
Vindhya Koneru1,2, William G Ondo1,2
1Department of Neurology Houston Methodist Neurological Institute, Houston Methodist Hospital Houston Texas USA.
Movement Disorders Clinical Practice
|January 11, 2021
Summary
Task-specific tremor (TST) may precede Parkinson's Disease (PD). In a series of 12 patients, TST was followed by PD symptoms, suggesting TST could be an early indicator of PD.
Area of Science:
- Neurology
- Movement Disorders
- Neurodegenerative Diseases
Background:
- Parkinson's Disease (PD) diagnosis can be complex, sometimes involving tremors.
- Task-specific tremor (TST) preceding PD is rarely reported, with its relationship to PD unclear.
Observation:
- A cohort of 12 patients with TST who later developed PD was identified.
- 11 patients with arm TST developed ipsilateral rest tremor.
- DaTscan revealed reduced dopaminergic uptake in 11 scanned patients.
Findings:
- TST appears to be a precursor to PD in this patient group.
- Ipsilateral rest tremor, positive DaTscan, and partial response to dopaminergic therapy support this.
- Treatment responses included Subthalamic Nucleus (STN) and Ventral Intermediate Nucleus (VIM) Deep Brain Stimulation (DBS), dopaminergic medications, and trihexyphenidyl.
Implications:
- This study suggests TST may serve as an early clinical sign of Parkinson's Disease.
- Understanding TST's role can aid in earlier PD diagnosis and management.
- Further research into the TST-PD connection is warranted.
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