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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

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Related Experiment Video

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Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons

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iPSC for modeling neurodegenerative disorders.

Valeria Valadez-Barba¹, A Cota-Coronado^1,2, O R Hernández-Pérez¹

¹Department of Medical and Pharmaceutical Biotechnology, Center for Research and Assistance in Technology and Design of the State of Jalisco, A.C. Av. Normalistas 800, Colinas de las Normal, Jalisco, Mexico, P.C.44270.

Regenerative Therapy

|January 11, 2021

Summary

Induced Pluripotent Stem Cells (iPSCs) offer a promising avenue for treating neurodegenerative diseases like Parkinson's and Alzheimer's. These versatile cells can be differentiated to replace damaged tissue and aid in developing new therapies and personalized medicine approaches.

Keywords:

AD, Alzheimer's disease AFP, Alpha-Fetoprotein Alzheimer Aβ, β-Amyloid B-III-TUB, β–III–Tubulin BBB, Blood Brain Barrier CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats DOPAL, 3,4-Dihydroxyphenylacetaldehyde EBs, Embryoid Bodies FLASH, Fast Length Adjustment of Short Reads LUHMES, Lund Human Mesencephalic Cell Line MHC, Mayor Histocompatibility Complex Neurodegenerative diseasaes PCR, Polymerase Chain Reaction PD, Parkinson's Disease Parkinson ROS, Reactive Oxygen Species SCs, Stem Cells SMA, Smooth-Muscle Antibody SNPc, Substantia Nigra Pars Compacta TH, Tyrosine Hydroxylase WGS, Whole Genome Sequencing gRNA, guide RNA hESC, Human Embryonic Stem Cells iPSCs iPSCs, Induced Pluripotent Stem Cells nsSNVs, nonsynonymous single nucleotide variants pTau, Phosphorylated Tau

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Area of Science:

Regenerative Medicine
Neuroscience
Stem Cell Biology

Background:

Neurodegenerative disorders, including Parkinson's and Alzheimer's disease, represent significant global health challenges.
Current research actively explores novel treatments and advanced techniques to combat these conditions.
Cell-based therapies and disease modeling are critical areas of investigation.

Purpose of the Study:

To review the application of induced Pluripotent Stem Cells (iPSCs) for cell-replacement therapy in neurodegenerative disorders.
To discuss the utility of iPSCs in disease modeling for understanding and treating conditions like Parkinson's and Alzheimer's.
To highlight the potential of iPSCs in advancing personalized medicine and drug discovery.

Main Methods:

Review of existing literature on induced Pluripotent Stem Cells (iPSCs).
Discussion of iPSC differentiation protocols for various cell types.
Analysis of *in vitro* and *in vivo* studies utilizing iPSCs for disease modeling and therapeutic development.

Main Results:

iPSCs can be differentiated into various cell types to potentially replace damaged cells in neurodegenerative diseases.
iPSC-derived models provide valuable platforms for studying disease mechanisms and testing potential drug candidates.
The application of iPSCs facilitates the discovery of biomarkers and supports personalized treatment strategies.

Conclusions:

Induced Pluripotent Stem Cells (iPSCs) hold significant promise for cell-replacement therapies in neurodegenerative disorders.
iPSCs are instrumental in creating accurate disease models for research and drug development.
The translation of iPSC technology offers a pathway toward personalized medicine for conditions like Parkinson's and Alzheimer's.