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The application of nanoparticles in cancer immunotherapy: Targeting tumor microenvironment

Muyue Yang1, Jipeng Li1, Ping Gu1

  • 1Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, 200011, China.

Bioactive Materials
|January 11, 2021
PubMed

Keywords:
AC-NPs, antigen-capturing nanoparticlesANG2, angiopoietin-2APCs, antigen-presenting cellsAb, antibodiesAg, antigenAuNCs, gold nanocagesAuNPs, gold nanoparticlesBBB, blood-brain barrierBTK, Bruton's tyrosine kinaseBcl-2, B-cell lymphoma 2CAFs, cancer associated fibroblastsCAP, cleavable amphiphilic peptideCAR-T, Chimeric antigen receptor-modified T-cell therapyCCL, chemoattractant chemokines ligandCTL, cytotoxic T lymphocytesCTLA4, cytotoxic lymphocyte antigen 4CaCO3, calcium carbonateCancer immunotherapyDCs, dendritic cellsDMMA, 2,3-dimethylmaleic anhydridDMXAA, 5,6-dimethylxanthenone-4-acetic acidDSF/Cu, disulfiram/copperECM, extracellular matrixEGFR, epidermal growth factor receptorEMT, epithelial-mesenchymal transitionEPG, egg phosphatidylglycerolEPR, enhanced permeability and retentionFAP, fibroblast activation proteinFDA, the Food and Drug AdministrationHA, hyaluronic acidHB-GFs, heparin-binding growth factorsHIF, hypoxia-inducible factorHPMA, N-(2-hydroxypropyl) methacrylamideHSA, human serum albuminHypoxiaIBR, IbrutinibIFN-γ, interferon-γIFP, interstitial fluid pressureIL, interleukinLMWH, low molecular weight heparinLPS, lipopolysaccharideM2NP, M2-like TAM dual-targeting nanoparticleMCMC, mannosylated carboxymethyl chitosanMDSCs, myeloid-derived suppressor cellsMPs, microparticlesMnO2, manganese dioxideNF-κB, nuclear factor κBNK, nature killerNO, nitric oxideNPs, nanoparticlesNanoparticlesODN, oligodeoxynucleotidesPD-1, programmed cell death protein 1PDT, photodynamic therapyPFC, perfluorocarbonPHDs, prolyl hydroxylasesPLGA, poly(lactic-co-glycolic acid)PS, photosensitizerPSCs, pancreatic stellate cellsPTX, paclitaxelRBC, red-blood-cellRLX, relaxin-2ROS, reactive oxygen speciesSA, sialic acidSPARC, secreted protein acidic and rich in cysteineTAAs, tumor-associated antigensTAMs, tumor-associated macrophagesTDPA, tumor-derived protein antigensTGF-β, transforming growth factor βTIE2, tyrosine kinase with immunoglobulin and epidermal growth factor homology domain 2TIM-3, T cell immunoglobulin domain and mucin domain-3TLR, Toll-like receptorTME, tumor microenvironmentTNF-α, tumor necrosis factor alphaTfR, transferrin receptorTregs, regulatory T cellsTumor microenvironmentUPS-NP, ultra-pH-sensitive nanoparticleVDA, vasculature disrupting agentVEGF, vascular endothelial growth factorcDCs, conventional dendritic cellsmelittin-NP, melittin-lipid nanoparticlenMOFs, nanoscale metal-organic frameworksscFv, single-chain variable fragmentsiRNA, small interfering RNAtdLNs, tumor-draining lymph nodesα-SMA, alpha-smooth muscle actin

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