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Engineered protein cages for selective heparin encapsulation
Salla Välimäki1, Qing Liu1, Lise Schoonen2
1Department of Bioproducts and Biosystems, Aalto University, P.O. Box 16100, Aalto FI-00076, Espoo, Finland. mauri.kostiainen@aalto.fi.
Journal of Materials Chemistry. B
|January 11, 2021
Abstract:
A heparin-specific binding peptide was conjugated to a cowpea chlorotic mottle virus (CCMV) capsid protein, which was subsequently allowed to encapsulate heparin and form capsid-like protein cages. The encapsulation is specific and the capsid-heparin assemblies display negligible hemolytic activity, indicating proper blood compatibility and promising possibilities for heparin antidote applications.

