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The immune dysregulations in COVID-19: Implications for the management of rheumatic diseases
Fan Xiao1, Man Han2, Xiaoxia Zhu3
1Department of Pathology and Shenzhen Institute of Research and Innovation, The University of Hong Kong and Chongqing International Institute for Immunology, Hong Kong, China.
Abstract:
The pandemic of COVID-19 has caused global social impact and high health risk. Clinical observations have suggested that elevated levels of inflammatory mediators are associated with disease severities in COVID-19 patients, in which the immunological profiles indicate the hyperactivation of innate immune cells and dysregulated adaptive immune responses. The increasing prevalence and disease progression of COVID-19 has emerged as a pressing challenge for the management of rheumatic patients with immune dysregulations. Here we review the immune dysregulations in COVID-19 and discuss the management of COVID-19 patients with rheumatic diseases.
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