Related Experiment Video
Updated: Nov 22, 2025
06:33
Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
Published on: November 10, 2023
1.6K
CCN2 (Cellular Communication Network factor 2) in the bone marrow microenvironment, normal and malignant
Roos J Leguit1, Reinier A P Raymakers2, Konnie M Hebeda3
1Department of Pathology, University Medical Center Utrecht, H04-312, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands. R.J.Leguit-2@umcutrecht.nl.
Journal of Cell Communication and Signaling
|January 11, 2021
Summary
Connective Tissue Growth Factor (CCN2) is crucial for bone marrow mesenchymal stem cell function and supports hematopoietic stem cell survival. Its dysregulation is linked to leukemia development and progression.
Area of Science:
- Biochemistry and Molecular Biology
- Hematology
- Cell Biology
Background:
- Connective Tissue Growth Factor (CCN2) is a matricellular protein regulating diverse cellular processes and implicated in fibrosis and cancer.
- CCN2 is highly expressed in bone marrow mesenchymal stem/stromal cells (MSCs), influencing their function and supporting hematopoietic stem cells (HSCs).
Purpose of the Study:
- To review the multifaceted role of CCN2 within the bone marrow microenvironment.
- To discuss CCN2's involvement in normal and malignant hematopoiesis.
- To provide an overview of other CCN family members' functions in hematopoiesis.
Main Methods:
- Literature review of existing studies on CCN2 and hematopoiesis.
- Analysis of CCN2 expression patterns in bone marrow and leukemic conditions.
- Comparison of CCN2 functions with other CCN family members in hematopoiesis.
Main Results:
- CCN2 is vital for MSC proliferation, migration, differentiation, and HSC survival.
- CCN2 promotes pro-B lymphocyte differentiation.
- CCN2 overexpression is associated with poor prognosis in B-acute lymphoblastic leukemia and increased leukemic engraftment in acute myeloid leukemia.
Conclusions:
- CCN2 plays a critical, context-dependent role in bone marrow function and hematopoiesis.
- CCN2 dysregulation contributes to leukemogenesis and impacts patient outcomes.
- Further research into CCN family members may reveal novel therapeutic targets in hematologic malignancies.
More Related Videos
10:03Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
Published on: August 1, 2017
12.0K
11:06Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches
Published on: March 21, 2017
8.1K
Related Concept Videos
01:01Regulation of Hematopoietic Stem Cells
3.6K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.6K
01:15Differentiation of Common Myeloid Progenitor Cells
3.6K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.6K
01:21Hematopoiesis
7.7K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
7.7K
01:28Role of Hematopoietic Growth Factors
2.6K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Thrombopoietin (TPO), mainly released by the liver,...
2.6K
01:26Stem Cell Niche
5.8K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
5.8K
01:19Multipotency of Hematopoietic Stem Cells
3.6K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.6K