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Establishment of a Valuable Mimic of Alzheimer's Disease in Rat Animal Model by Intracerebroventricular Injection of Composited Amyloid Beta Protein
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Establishment of a Valuable Mimic of Alzheimer's Disease in Rat Animal Model by Intracerebroventricular Injection of Composited Amyloid Beta Protein

Published on: July 29, 2018

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Advances in Drug Therapy for Alzheimer's Disease

Chuan-Cong Zhu1, Si-Yu Fu1, Yu-Xin Chen1

  • 1Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Current Medical Science
|January 11, 2021
PubMed

Insights

Developing effective Alzheimer's disease (AD) treatments remains challenging. Multi-drug combinations and early diagnosis offer promising strategies to combat this neurodegenerative disease and its dementia symptoms.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Gerontology

Background:

  • Alzheimer's disease (AD) is a leading cause of dementia in the elderly.
  • Current drug development focuses on amyloid-beta (Aβ) toxicity and tau hyperphosphorylation.
  • Other investigated mechanisms include neuroinflammation, oxidative damage, and neuron loss.

Purpose of the Study:

  • To review current drug therapy development for Alzheimer's disease.
  • To explore novel therapeutic strategies for AD.
  • To highlight the potential of combination therapies and early diagnosis.

Main Methods:

  • Review of existing and clinical trial-stage AD drug therapies.
  • Analysis of established AD pathological mechanisms.
  • Exploration of emerging therapeutic approaches.

Main Results:

  • Limited success of current single-target drugs in improving AD symptoms or progression.
  • Emerging potential of multi-drug combinations as a therapeutic avenue.
  • Importance of early AD diagnosis for effective intervention.

Conclusions:

  • Current AD drug therapies show limited efficacy.
  • Combination therapies and early intervention are crucial for managing Alzheimer's disease.
  • Further research into novel therapeutic strategies is warranted.
Keywords:
Alzheimer’s diseaseAβdrug therapytau

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