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Updated: Nov 22, 2025

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels
Published on: May 26, 2023
Clinical impact of the repair technique for posterior mitral leaflet prolapse: Resect or respect?
Taichi Sakaguchi1, Arudo Hiraoka2, Toshinori Totsugawa2
1Department of Cardiovascular Surgery, Hyogo College of Medicine, Hyogo, Japan.
Background And Aim:
Leaflet resection and chordal reconstruction are established repair techniques for posterior mitral valve (MV) prolapse. This study aimed to compare the clinical results of the resect and respect approaches, with a particular focus on MV hemodynamics.
Methods:
Overall, 291 patients who underwent elective MV repair for isolated posterior leaflet prolapse between 2012 and 2020 were enrolled. Patients who underwent leaflet resection alone were classified as the "resection" group (n = 166), while patients who underwent neochordal replacement with/without limited leaflet resection were classified as the "respect" group (n = 125). Early postoperative MV hemodynamics and midterm repair durability were compared between the groups.
Results:
The annuloplasty ring size was significantly larger in the respect group than in the resection group (31.0 ± 2.1 vs. 30.4 ± 2.0 mm, p = .028). The respect group showed significantly lower mean MV gradient (2.6 ± 1.1 vs. 3.0 ± 1.4 mmHg, p = .03) and larger effective orifice area (EOA) (1.86 ± 0.48 vs. 1.66 ± 0.47 cm2 , p < .001) than the resection group. Multivariable analysis identified the respect approach, younger age, female sex, larger ring size, and partial band as independent determinants of larger EOA. The rate of freedom from moderate or greater recurrent mitral regurgitation 5 years postoperatively was 90.9% in both groups.
Conclusions:
The respect approach allowed for a lower MV gradient and a larger EOA than the resection approach, which is possibly due to the capability of implanting a larger annuloplasty ring.
Insights
The "respect" approach for mitral valve prolapse repair resulted in better hemodynamics, including a lower gradient and larger effective orifice area, compared to the "resection" method. Both techniques demonstrated similar midterm durability.
Area of Science:
- Cardiovascular Surgery
- Cardiac Surgery
- Mitral Valve Repair
Background:
- Posterior mitral valve prolapse is commonly repaired using leaflet resection or chordal reconstruction.
- Established techniques include leaflet resection and chordal reconstruction for posterior mitral valve prolapse.
Purpose of the Study:
- To compare the clinical outcomes of the "resect" and "respect" surgical approaches for posterior mitral valve prolapse.
- To evaluate the impact of these techniques on mitral valve hemodynamics and repair durability.
Main Methods:
- A cohort of 291 patients undergoing elective mitral valve repair for isolated posterior leaflet prolapse was analyzed.
- Patients were categorized into "resection" (leaflet resection alone) and "respect" (neochordal replacement) groups.
- Early postoperative hemodynamics and midterm repair durability were compared between the two groups.
Main Results:
- The "respect" group utilized significantly larger annuloplasty rings (31.0 vs. 30.4 mm).
- The "respect" group exhibited a lower mean mitral valve gradient (2.6 vs. 3.0 mmHg) and a larger effective orifice area (1.86 vs. 1.66 cm²).
- Five-year freedom from moderate or greater mitral regurgitation was high and similar in both groups (90.9%).
Conclusions:
- The "respect" approach for mitral valve prolapse repair leads to improved hemodynamic function, evidenced by lower gradients and larger effective orifice areas.
- This hemodynamic benefit may be attributed to the ability to implant larger annuloplasty rings with the "respect" technique.
- Both "resect" and "respect" approaches offer comparable midterm durability for mitral valve repair.
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