Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Retinal dystrophy in Wistar-Furth rats.

W L Lin1, E Essner

  • 1Kresge Eye Institute, Wayne State University School of Medicine, Detroit, MI 48201.

Experimental Eye Research
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pulmonary nodule malignancy probability: a meta-analysis of the Brock model.

Clinical radiology·2025
Same author

A critically ill infant with multi-organ dysfunction due to eczema.

Hong Kong medical journal = Xianggang yi xue za zhi·2022
Same author

[Effect of phacoemulsification on the Berger space].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology·2022
Same author

[Analysis of 2 diagnostic criteria of echocardiography for coronary artery aneurysm in Kawasaki disease].

Zhonghua er ke za zhi = Chinese journal of pediatrics·2022
Same author

Tumour-shrinking decoction for symptomatic uterine fibroids: a double-blind, randomised, two-dose trial (abridged secondary publication).

Hong Kong medical journal = Xianggang yi xue za zhi·2021
Same author

Roles and challenges of traditional Chinese medicine in COVID-19 in Hong Kong.

Hong Kong medical journal = Xianggang yi xue za zhi·2020
Same journal

Caffeine suppresses inflammation and subretinal fibrosis through modulation of the thrombospondin-1-Bim axis.

Experimental eye research·2026
Same journal

Single-cell transcriptomic profiling reveals functional heterogeneity and regulatory programs of neutrophils in experimental autoimmune uveitis.

Experimental eye research·2026
Same journal

Three-Dimensional Platform-Dependent Modulation of Stemness and EMT-Associated Gene Expression in Primary and Metastatic Uveal Melanoma Models.

Experimental eye research·2026
Same journal

Early Proteomic and Metabolic Signatures of Liver and Eye in OAT-Deficient Mice.

Experimental eye research·2026
Same journal

Inhibition of STAT6 signaling by rebamipide attenuates IL-4- and IL-13-induced eotaxin expression in corneal fibroblasts.

Experimental eye research·2026
Same journal

Translational animal model for genetic predisposition to anophthalmia/microphthalmia.

Experimental eye research·2026
See all related articles

This study details retinal degeneration in Wistar-Furth rats, observing mild to severe changes in photoreceptors and retinal pigment epithelium (RPE). These findings offer insights into progressive vision loss mechanisms.

Area of Science:

  • Ophthalmology
  • Veterinary Pathology
  • Cell Biology

Background:

  • Retinal degeneration is a significant cause of vision impairment.
  • Understanding the mechanisms of retinal dystrophy is crucial for developing therapeutic strategies.
  • The Wistar-Furth rat strain serves as a model for studying inherited retinal diseases.

Purpose of the Study:

  • To characterize the morphological changes associated with retinal degeneration in Wistar-Furth rats.
  • To classify the stages of retinal dystrophy based on histopathological findings.
  • To investigate the involvement of the retinal pigment epithelium (RPE) and retinal vasculature in the disease process.

Main Methods:

  • Light and electron microscopy were employed to examine retinal tissues.

Related Experiment Videos

  • Histopathological analysis was performed to identify cellular and structural alterations.
  • Intravenously injected peroxidase was used to assess the integrity of the retinal pigment epithelium tight junctions.

    • Main Results:

    • Mild degeneration showed decreased photoreceptor nuclei in the outer nuclear layer (ONL) and focal swellings of photoreceptor segments.
    • Severe degeneration involved further ONL thinning, photoreceptor degeneration, and RPE basal membrane alterations.
    • Advanced stages included RPE vascularization, fenestrated intra-RPE vessels, and changes in retinal capillaries and Bruch's membrane.

    Conclusions:

    • Wistar-Furth rats exhibit progressive retinal degeneration with distinct mild and severe stages.
    • The retinal pigment epithelium and vasculature are significantly affected during the progression of this dystrophy.
    • This model provides valuable insights into the cellular and structural pathology of retinal degeneration.